Cargando…
A dual-action antibiotic that kills Clostridioides difficile vegetative cells and inhibits spore germination
Clostridioides difficile infection (CDI) is the most lethal of the five CDC urgent public health treats, resulting in 12,800 annual deaths in the United States alone [Antibiotic Resistance Threats in the United States, 2019 (2019), www.cdc.gov/DrugResistance/Biggest-Threats.html]. The high recurrenc...
Autores principales: | Janardhanan, Jeshina, Kim, Choon, Qian, Yuanyuan, Yang, Jingdong, Meisel, Jayda E., Ding, Derong, Speri, Enrico, Schroeder, Valerie A., Wolter, William R., Oliver, Allen G., Mobashery, Shahriar, Chang, Mayland |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193928/ https://www.ncbi.nlm.nih.gov/pubmed/37155891 http://dx.doi.org/10.1073/pnas.2304110120 |
Ejemplares similares
-
Teicoplanin Suppresses Vegetative Clostridioides difficile and Spore Outgrowth
por: Ojha, Suvash Chandra, et al.
Publicado: (2021) -
Convenient Protocol for Production and Purification of Clostridioides difficile Spores for Germination Studies
por: Weldy, Melissa, et al.
Publicado: (2020) -
Differential effects of ‘resurrecting' Csp pseudoproteases during Clostridioides difficile spore germination
por: Donnelly, M. Lauren, et al.
Publicado: (2020) -
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals
por: Rohlfing, Amy E., et al.
Publicado: (2019) -
Single-spore germination analyses reveal that calcium released during Clostridioides difficile germination functions in a feedforward loop
por: Ribis, John W., et al.
Publicado: (2023)