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Croquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193931/ https://www.ncbi.nlm.nih.gov/pubmed/37155900 http://dx.doi.org/10.1073/pnas.2208673120 |
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author | O’Neal, Anya J. Singh, Nisha Rolandelli, Agustin Laukaitis, Hanna J. Wang, Xiaowei Shaw, Dana K. Young, Brianna D. Narasimhan, Sukanya Dutta, Shraboni Snyder, Greg A. Samaddar, Sourabh Marnin, Liron Butler, L. Rainer Mendes, M. Tays Cabrera Paz, Francy E. Valencia, Luisa M. Sundberg, Eric J. Fikrig, Erol Pal, Utpal Weber, David J. Pedra, Joao H. F. |
author_facet | O’Neal, Anya J. Singh, Nisha Rolandelli, Agustin Laukaitis, Hanna J. Wang, Xiaowei Shaw, Dana K. Young, Brianna D. Narasimhan, Sukanya Dutta, Shraboni Snyder, Greg A. Samaddar, Sourabh Marnin, Liron Butler, L. Rainer Mendes, M. Tays Cabrera Paz, Francy E. Valencia, Luisa M. Sundberg, Eric J. Fikrig, Erol Pal, Utpal Weber, David J. Pedra, Joao H. F. |
author_sort | O’Neal, Anya J. |
collection | PubMed |
description | The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain elusive. Here, we show that an Ixodes scapularis homolog of croquemort (Crq), a CD36-like protein, promotes activation of the tick IMD pathway. Crq exhibits plasma membrane localization and binds the lipid agonist 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol. Crq regulates the IMD and jun N-terminal kinase signaling cascades and limits the acquisition of the Lyme disease spirochete B. burgdorferi. Additionally, nymphs silenced for crq display impaired feeding and delayed molting to adulthood due to a deficiency in ecdysteroid synthesis. Collectively, we establish a distinct mechanism for arthropod immunity outside of insects and crustaceans. |
format | Online Article Text |
id | pubmed-10193931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-101939312023-11-08 Croquemort elicits activation of the immune deficiency pathway in ticks O’Neal, Anya J. Singh, Nisha Rolandelli, Agustin Laukaitis, Hanna J. Wang, Xiaowei Shaw, Dana K. Young, Brianna D. Narasimhan, Sukanya Dutta, Shraboni Snyder, Greg A. Samaddar, Sourabh Marnin, Liron Butler, L. Rainer Mendes, M. Tays Cabrera Paz, Francy E. Valencia, Luisa M. Sundberg, Eric J. Fikrig, Erol Pal, Utpal Weber, David J. Pedra, Joao H. F. Proc Natl Acad Sci U S A Biological Sciences The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain elusive. Here, we show that an Ixodes scapularis homolog of croquemort (Crq), a CD36-like protein, promotes activation of the tick IMD pathway. Crq exhibits plasma membrane localization and binds the lipid agonist 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol. Crq regulates the IMD and jun N-terminal kinase signaling cascades and limits the acquisition of the Lyme disease spirochete B. burgdorferi. Additionally, nymphs silenced for crq display impaired feeding and delayed molting to adulthood due to a deficiency in ecdysteroid synthesis. Collectively, we establish a distinct mechanism for arthropod immunity outside of insects and crustaceans. National Academy of Sciences 2023-05-08 2023-05-16 /pmc/articles/PMC10193931/ /pubmed/37155900 http://dx.doi.org/10.1073/pnas.2208673120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences O’Neal, Anya J. Singh, Nisha Rolandelli, Agustin Laukaitis, Hanna J. Wang, Xiaowei Shaw, Dana K. Young, Brianna D. Narasimhan, Sukanya Dutta, Shraboni Snyder, Greg A. Samaddar, Sourabh Marnin, Liron Butler, L. Rainer Mendes, M. Tays Cabrera Paz, Francy E. Valencia, Luisa M. Sundberg, Eric J. Fikrig, Erol Pal, Utpal Weber, David J. Pedra, Joao H. F. Croquemort elicits activation of the immune deficiency pathway in ticks |
title | Croquemort elicits activation of the immune deficiency pathway in ticks |
title_full | Croquemort elicits activation of the immune deficiency pathway in ticks |
title_fullStr | Croquemort elicits activation of the immune deficiency pathway in ticks |
title_full_unstemmed | Croquemort elicits activation of the immune deficiency pathway in ticks |
title_short | Croquemort elicits activation of the immune deficiency pathway in ticks |
title_sort | croquemort elicits activation of the immune deficiency pathway in ticks |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193931/ https://www.ncbi.nlm.nih.gov/pubmed/37155900 http://dx.doi.org/10.1073/pnas.2208673120 |
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