S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling

KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the presence of electrophilic agents by modification of its sensor cysteine residues. In addition to xenobiotics, seve...

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Detalles Bibliográficos
Autores principales: Ko, Yeonjin, Hong, Mannkyu, Lee, Seungbeom, Kumar, Manoj, Ibrahim, Lara, Nutsch, Kayla, Stanton, Caroline, Sondermann, Phillip, Sandoval, Braddock, Bulos, Maya L., Iaconelli, Jonathan, Chatterjee, Arnab K., Wiseman, R. Luke, Schultz, Peter G., Bollong, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193962/
https://www.ncbi.nlm.nih.gov/pubmed/37155889
http://dx.doi.org/10.1073/pnas.2300763120

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