Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity

In 2021, the World Health Organization reclassified glioblastoma, the most common form of adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade IV IDH mutant (G4 IDHm) astrocytomas. For both tumor types, intratumoral heterogeneity is a key contributor to therapeut...

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Detalles Bibliográficos
Autores principales: Raviram, Ramya, Raman, Anugraha, Preissl, Sebastian, Ning, Jiangfang, Wu, Shaoping, Koga, Tomoyuki, Zhang, Kai, Brennan, Cameron W., Zhu, Chenxu, Luebeck, Jens, Van Deynze, Kinsey, Han, Jee Yun, Hou, Xiaomeng, Ye, Zhen, Mischel, Anna K., Li, Yang Eric, Fang, Rongxin, Baback, Tomas, Mugford, Joshua, Han, Claudia Z., Glass, Christopher K., Barr, Cathy L., Mischel, Paul S., Bafna, Vineet, Escoubet, Laure, Ren, Bing, Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194019/
https://www.ncbi.nlm.nih.gov/pubmed/37155843
http://dx.doi.org/10.1073/pnas.2210991120

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