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The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes

BACKGROUND & AIMS: The effect of change in non-alcoholic fatty liver disease (NAFLD) status on incident diabetes has not been well studied. We aimed to investigate the association of NAFLD development and remission with the risk of incident diabetes during a median of 3.5-year follow-up. METHODS...

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Autores principales: Chen, Congling, Zhang, Yuecheng, Fan, Yujuan, Ying, Zhen, Su, Qing, Li, Xiaoying, Qin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194027/
https://www.ncbi.nlm.nih.gov/pubmed/37214244
http://dx.doi.org/10.3389/fendo.2023.1108442
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author Chen, Congling
Zhang, Yuecheng
Fan, Yujuan
Ying, Zhen
Su, Qing
Li, Xiaoying
Qin, Li
author_facet Chen, Congling
Zhang, Yuecheng
Fan, Yujuan
Ying, Zhen
Su, Qing
Li, Xiaoying
Qin, Li
author_sort Chen, Congling
collection PubMed
description BACKGROUND & AIMS: The effect of change in non-alcoholic fatty liver disease (NAFLD) status on incident diabetes has not been well studied. We aimed to investigate the association of NAFLD development and remission with the risk of incident diabetes during a median of 3.5-year follow-up. METHODS: A total of 2690 participants without diabetes were recruited in 2011-2012 and assessed for incident diabetes in 2014. Abdominal ultrasonography was used to determine the change of NAFLD. 75 g oral glucose tolerance test (OGTT) was performed to determine diabetes. NAFLD severity was assessed using Gholam’s model. The odds ratios (ORs) for incident diabetes were estimated by logistic regression models. RESULTS: NAFLD was developed in 580 (33.2%) participants and NAFLD remission occurred in 150 (15.9%) participants during a median of 3.5-year follow-up. A total of 484 participants developed diabetes during follow-up, including 170 (14.6%) in consistent non-NAFLD group, 111 (19.1%) in NAFLD developed group, 19 (12.7%) in NAFLD remission group, and 184 (23.2%) in sustained NAFLD group. The development of NAFLD increased the risk of incident diabetes by 43% (OR, 1.43; 95%CI, 1.10-1.86) after adjustment for multiple confounders. Compared with sustained NAFLD group, remission of NAFLD reduced the risk of incident diabetes by 52% (OR, 0.48; 95%CI, 0.29-0.80). The effect of NAFLD alteration on incident diabetes was not changed after adjustment for body mass index or waist circumference, change of body mass index or waist circumference. In NAFLD remission group, participants with non-alcoholic steatohepatitis (NASH) at baseline were more likely to develop diabetes (OR, 3.03; 95%CI, 1.01-9.12). CONCLUSIONS: NAFLD development increases the risk of incident diabetes, whereas NAFLD remission reduces the risk of incident diabetes. Moreover, presence of NASH at baseline could attenuate the protective effect of NAFLD remission on incident diabetes. Our study suggests that early intervention of NAFLD and maintenance of non-NAFLD are important for prevention of diabetes.
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spelling pubmed-101940272023-05-19 The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes Chen, Congling Zhang, Yuecheng Fan, Yujuan Ying, Zhen Su, Qing Li, Xiaoying Qin, Li Front Endocrinol (Lausanne) Endocrinology BACKGROUND & AIMS: The effect of change in non-alcoholic fatty liver disease (NAFLD) status on incident diabetes has not been well studied. We aimed to investigate the association of NAFLD development and remission with the risk of incident diabetes during a median of 3.5-year follow-up. METHODS: A total of 2690 participants without diabetes were recruited in 2011-2012 and assessed for incident diabetes in 2014. Abdominal ultrasonography was used to determine the change of NAFLD. 75 g oral glucose tolerance test (OGTT) was performed to determine diabetes. NAFLD severity was assessed using Gholam’s model. The odds ratios (ORs) for incident diabetes were estimated by logistic regression models. RESULTS: NAFLD was developed in 580 (33.2%) participants and NAFLD remission occurred in 150 (15.9%) participants during a median of 3.5-year follow-up. A total of 484 participants developed diabetes during follow-up, including 170 (14.6%) in consistent non-NAFLD group, 111 (19.1%) in NAFLD developed group, 19 (12.7%) in NAFLD remission group, and 184 (23.2%) in sustained NAFLD group. The development of NAFLD increased the risk of incident diabetes by 43% (OR, 1.43; 95%CI, 1.10-1.86) after adjustment for multiple confounders. Compared with sustained NAFLD group, remission of NAFLD reduced the risk of incident diabetes by 52% (OR, 0.48; 95%CI, 0.29-0.80). The effect of NAFLD alteration on incident diabetes was not changed after adjustment for body mass index or waist circumference, change of body mass index or waist circumference. In NAFLD remission group, participants with non-alcoholic steatohepatitis (NASH) at baseline were more likely to develop diabetes (OR, 3.03; 95%CI, 1.01-9.12). CONCLUSIONS: NAFLD development increases the risk of incident diabetes, whereas NAFLD remission reduces the risk of incident diabetes. Moreover, presence of NASH at baseline could attenuate the protective effect of NAFLD remission on incident diabetes. Our study suggests that early intervention of NAFLD and maintenance of non-NAFLD are important for prevention of diabetes. Frontiers Media S.A. 2023-05-04 /pmc/articles/PMC10194027/ /pubmed/37214244 http://dx.doi.org/10.3389/fendo.2023.1108442 Text en Copyright © 2023 Chen, Zhang, Fan, Ying, Su, Li and Qin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Congling
Zhang, Yuecheng
Fan, Yujuan
Ying, Zhen
Su, Qing
Li, Xiaoying
Qin, Li
The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
title The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
title_full The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
title_fullStr The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
title_full_unstemmed The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
title_short The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
title_sort change of non-alcoholic fatty liver disease is associated with risk of incident diabetes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194027/
https://www.ncbi.nlm.nih.gov/pubmed/37214244
http://dx.doi.org/10.3389/fendo.2023.1108442
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