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Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020

INTRODUCTION: Diabetes is one of the comorbidities associated with poor prognosis in hospitalized COVID-19 patients. In this nationwide retrospective study, we evaluated the risk of in-hospital death attributed to diabetes. METHODS: We analyzed data from discharge reports of patients hospitalized wi...

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Autores principales: Kania, Michal, Koń, Beata, Kamiński, Konrad, Hohendorff, Jerzy, Witek, Przemysław, Klupa, Tomasz, Malecki, Maciej T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194032/
https://www.ncbi.nlm.nih.gov/pubmed/37214252
http://dx.doi.org/10.3389/fendo.2023.1161637
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author Kania, Michal
Koń, Beata
Kamiński, Konrad
Hohendorff, Jerzy
Witek, Przemysław
Klupa, Tomasz
Malecki, Maciej T.
author_facet Kania, Michal
Koń, Beata
Kamiński, Konrad
Hohendorff, Jerzy
Witek, Przemysław
Klupa, Tomasz
Malecki, Maciej T.
author_sort Kania, Michal
collection PubMed
description INTRODUCTION: Diabetes is one of the comorbidities associated with poor prognosis in hospitalized COVID-19 patients. In this nationwide retrospective study, we evaluated the risk of in-hospital death attributed to diabetes. METHODS: We analyzed data from discharge reports of patients hospitalized with COVID-19 in 2020 as submitted to the Polish National Health Fund. Several multivariate logistic regression models were used. In each model, in-hospital death was estimated with explanatory variables. Models were built either on the whole cohorts or cohorts matched with propensity score matching (PSM). The models examined either the main effects of diabetes itself or the interaction of diabetes with other variables. RESULTS: We included 174,621 patients with COVID-19 who were hospitalized in the year 2020. Among them, there were 40,168 diabetic patients (DPs), and the proportion of DPs in this group was higher than in the general population (23.0% vs. 9.5%, p<0.001). In this group of COVID-19 hospitalizations, 17,438 in-hospital deaths were recorded, and the mortality was higher among DPs than non-diabetics (16.3% vs. 8.1%, p<0.001). Multivariate logistic regressions showed that diabetes was a risk factor of death, regardless of sex and age. In the main effect analysis, odds of in-hospital death were higher by 28.3% for DPs than for non-diabetic patients. Similarly, PSM analysis including 101,578 patients, of whom 19,050 had diabetes, showed that the risk of death was higher in DPs regardless of sex with odds higher by 34.9%. The impact of diabetes differed among age groups and was the highest for patients aged 60-69. CONCLUSIONS: This nationwide study confirmed that diabetes was an independent risk factor of in-hospital death in the course of COVID-19 infection. However, the relative risk differed across the age groups.
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spelling pubmed-101940322023-05-19 Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020 Kania, Michal Koń, Beata Kamiński, Konrad Hohendorff, Jerzy Witek, Przemysław Klupa, Tomasz Malecki, Maciej T. Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Diabetes is one of the comorbidities associated with poor prognosis in hospitalized COVID-19 patients. In this nationwide retrospective study, we evaluated the risk of in-hospital death attributed to diabetes. METHODS: We analyzed data from discharge reports of patients hospitalized with COVID-19 in 2020 as submitted to the Polish National Health Fund. Several multivariate logistic regression models were used. In each model, in-hospital death was estimated with explanatory variables. Models were built either on the whole cohorts or cohorts matched with propensity score matching (PSM). The models examined either the main effects of diabetes itself or the interaction of diabetes with other variables. RESULTS: We included 174,621 patients with COVID-19 who were hospitalized in the year 2020. Among them, there were 40,168 diabetic patients (DPs), and the proportion of DPs in this group was higher than in the general population (23.0% vs. 9.5%, p<0.001). In this group of COVID-19 hospitalizations, 17,438 in-hospital deaths were recorded, and the mortality was higher among DPs than non-diabetics (16.3% vs. 8.1%, p<0.001). Multivariate logistic regressions showed that diabetes was a risk factor of death, regardless of sex and age. In the main effect analysis, odds of in-hospital death were higher by 28.3% for DPs than for non-diabetic patients. Similarly, PSM analysis including 101,578 patients, of whom 19,050 had diabetes, showed that the risk of death was higher in DPs regardless of sex with odds higher by 34.9%. The impact of diabetes differed among age groups and was the highest for patients aged 60-69. CONCLUSIONS: This nationwide study confirmed that diabetes was an independent risk factor of in-hospital death in the course of COVID-19 infection. However, the relative risk differed across the age groups. Frontiers Media S.A. 2023-05-04 /pmc/articles/PMC10194032/ /pubmed/37214252 http://dx.doi.org/10.3389/fendo.2023.1161637 Text en Copyright © 2023 Kania, Koń, Kamiński, Hohendorff, Witek, Klupa and Malecki https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Kania, Michal
Koń, Beata
Kamiński, Konrad
Hohendorff, Jerzy
Witek, Przemysław
Klupa, Tomasz
Malecki, Maciej T.
Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020
title Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020
title_full Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020
title_fullStr Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020
title_full_unstemmed Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020
title_short Diabetes as a risk factor of death in hospitalized COVID-19 patients – an analysis of a National Hospitalization Database from Poland, 2020
title_sort diabetes as a risk factor of death in hospitalized covid-19 patients – an analysis of a national hospitalization database from poland, 2020
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194032/
https://www.ncbi.nlm.nih.gov/pubmed/37214252
http://dx.doi.org/10.3389/fendo.2023.1161637
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