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Targeting HDAC11 activity by FT895 restricts EV71 replication

Enterovirus 71 (EV71) infection mainly causes hand, foot, and mouth disease (HFMD) and remains a serious public health problem to the children under the age of 5. Until now, there is no specific drug to treat HFMD in clinical and there is an urgent to explore the new target and the new drug to addre...

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Detalles Bibliográficos
Autores principales: Xie, Hong, Yang, Enhui, Wang, Chaoyong, Peng, Chunyan, Ji, Lianfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194106/
https://www.ncbi.nlm.nih.gov/pubmed/37024058
http://dx.doi.org/10.1016/j.virusres.2023.199108
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author Xie, Hong
Yang, Enhui
Wang, Chaoyong
Peng, Chunyan
Ji, Lianfu
author_facet Xie, Hong
Yang, Enhui
Wang, Chaoyong
Peng, Chunyan
Ji, Lianfu
author_sort Xie, Hong
collection PubMed
description Enterovirus 71 (EV71) infection mainly causes hand, foot, and mouth disease (HFMD) and remains a serious public health problem to the children under the age of 5. Until now, there is no specific drug to treat HFMD in clinical and there is an urgent to explore the new target and the new drug to address clinical challenges. At present, we found histone deacetylase 11 (HDAC11) involves in supporting EV71 replication. We also used HDAC11 siRNA and an HDAC11 inhibitor FT895 to downregulate HDAC11 expression and found that targeting HDAC11 could significantly restrict EV71 replication in vitro and in vivo. Our results revealed the new role of HDAC11 participating in EV71 replication and broadened our knowledge regarding the functions of HDAC11 and the roles of HDACs in the epigenetic regulation of viral infectious diseases. Our results for the first time identified FT895 as an effective inhibitor of EV71 in vitro and in vivo, which may contribute to be a potential drug to treat HFMD.
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spelling pubmed-101941062023-05-19 Targeting HDAC11 activity by FT895 restricts EV71 replication Xie, Hong Yang, Enhui Wang, Chaoyong Peng, Chunyan Ji, Lianfu Virus Res Article Enterovirus 71 (EV71) infection mainly causes hand, foot, and mouth disease (HFMD) and remains a serious public health problem to the children under the age of 5. Until now, there is no specific drug to treat HFMD in clinical and there is an urgent to explore the new target and the new drug to address clinical challenges. At present, we found histone deacetylase 11 (HDAC11) involves in supporting EV71 replication. We also used HDAC11 siRNA and an HDAC11 inhibitor FT895 to downregulate HDAC11 expression and found that targeting HDAC11 could significantly restrict EV71 replication in vitro and in vivo. Our results revealed the new role of HDAC11 participating in EV71 replication and broadened our knowledge regarding the functions of HDAC11 and the roles of HDACs in the epigenetic regulation of viral infectious diseases. Our results for the first time identified FT895 as an effective inhibitor of EV71 in vitro and in vivo, which may contribute to be a potential drug to treat HFMD. Elsevier 2023-04-15 /pmc/articles/PMC10194106/ /pubmed/37024058 http://dx.doi.org/10.1016/j.virusres.2023.199108 Text en © 2023 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Xie, Hong
Yang, Enhui
Wang, Chaoyong
Peng, Chunyan
Ji, Lianfu
Targeting HDAC11 activity by FT895 restricts EV71 replication
title Targeting HDAC11 activity by FT895 restricts EV71 replication
title_full Targeting HDAC11 activity by FT895 restricts EV71 replication
title_fullStr Targeting HDAC11 activity by FT895 restricts EV71 replication
title_full_unstemmed Targeting HDAC11 activity by FT895 restricts EV71 replication
title_short Targeting HDAC11 activity by FT895 restricts EV71 replication
title_sort targeting hdac11 activity by ft895 restricts ev71 replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194106/
https://www.ncbi.nlm.nih.gov/pubmed/37024058
http://dx.doi.org/10.1016/j.virusres.2023.199108
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