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Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic autoimmune disease that typically presents as a multi-organ manifesting disease of unclear etiology that can predispose to rapidly progressive glomerulonephritis (RPGN). If left untreated, ANCA-associated vasculitis can...

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Autores principales: Tahir, Ali, Walia, Jasmit, Daly, Timothy, Gradzka, Alexandra, Banai, Ruslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194189/
https://www.ncbi.nlm.nih.gov/pubmed/37214004
http://dx.doi.org/10.7759/cureus.37767
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author Tahir, Ali
Walia, Jasmit
Daly, Timothy
Gradzka, Alexandra
Banai, Ruslan
author_facet Tahir, Ali
Walia, Jasmit
Daly, Timothy
Gradzka, Alexandra
Banai, Ruslan
author_sort Tahir, Ali
collection PubMed
description Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic autoimmune disease that typically presents as a multi-organ manifesting disease of unclear etiology that can predispose to rapidly progressive glomerulonephritis (RPGN). If left untreated, ANCA-associated vasculitis can be fatal, and RPGN can progress to irreversible renal failure. Environmental and genetic factors have been implicated in the pathogenesis of this vasculitis. Coronavirus disease (COVID-19) has been noted to have various physiologic impacts on the body, with literature indicating possible autoimmune effects. We present a rare case of ANCA-associated vasculitis in an elderly male with no known autoimmune history after a recent illness with COVID-19. The patient had been seen as an outpatient with progressively declining renal function until he presented to the hospital with acute renal failure and pericarditis. Workup revealed elevated anti-myeloperoxidase antibody (MPO-AB) and perinuclear ANCA (p-ANCA) antibodies with a biopsy confirming focal cresenteric glomerulonephritis, and the patient was initiated on steroid therapy with notable improvement and a return to baseline kidney function.
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spelling pubmed-101941892023-05-19 Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report Tahir, Ali Walia, Jasmit Daly, Timothy Gradzka, Alexandra Banai, Ruslan Cureus Internal Medicine Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic autoimmune disease that typically presents as a multi-organ manifesting disease of unclear etiology that can predispose to rapidly progressive glomerulonephritis (RPGN). If left untreated, ANCA-associated vasculitis can be fatal, and RPGN can progress to irreversible renal failure. Environmental and genetic factors have been implicated in the pathogenesis of this vasculitis. Coronavirus disease (COVID-19) has been noted to have various physiologic impacts on the body, with literature indicating possible autoimmune effects. We present a rare case of ANCA-associated vasculitis in an elderly male with no known autoimmune history after a recent illness with COVID-19. The patient had been seen as an outpatient with progressively declining renal function until he presented to the hospital with acute renal failure and pericarditis. Workup revealed elevated anti-myeloperoxidase antibody (MPO-AB) and perinuclear ANCA (p-ANCA) antibodies with a biopsy confirming focal cresenteric glomerulonephritis, and the patient was initiated on steroid therapy with notable improvement and a return to baseline kidney function. Cureus 2023-04-18 /pmc/articles/PMC10194189/ /pubmed/37214004 http://dx.doi.org/10.7759/cureus.37767 Text en Copyright © 2023, Tahir et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Tahir, Ali
Walia, Jasmit
Daly, Timothy
Gradzka, Alexandra
Banai, Ruslan
Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
title Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
title_full Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
title_fullStr Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
title_full_unstemmed Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
title_short Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
title_sort rapidly progressive glomerulonephritis: a covid-19 case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194189/
https://www.ncbi.nlm.nih.gov/pubmed/37214004
http://dx.doi.org/10.7759/cureus.37767
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