Cargando…

Possible etiological association of ovine papillomaviruses with bladder tumors in cattle

INTRODUCTION: Bladder tumors of cattle are very uncommon accounting from 0.1% to 0.01% of all bovine malignancies. Bladder tumors are common in cattle grazing on bracken fern-infested pasturelands. Bovine papillomaviruses have a crucial role in tumors of bovine urinary bladder. AIM OF THE STUDY: To...

Descripción completa

Detalles Bibliográficos
Autores principales: De Falco, Francesca, Cuccaro, Bianca, De Tullio, Roberta, Alberti, Alberto, Cutarelli, Anna, De Carlo, Esterina, Roperto, Sante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194246/
https://www.ncbi.nlm.nih.gov/pubmed/36878382
http://dx.doi.org/10.1016/j.virusres.2023.199084
_version_ 1785043978260840448
author De Falco, Francesca
Cuccaro, Bianca
De Tullio, Roberta
Alberti, Alberto
Cutarelli, Anna
De Carlo, Esterina
Roperto, Sante
author_facet De Falco, Francesca
Cuccaro, Bianca
De Tullio, Roberta
Alberti, Alberto
Cutarelli, Anna
De Carlo, Esterina
Roperto, Sante
author_sort De Falco, Francesca
collection PubMed
description INTRODUCTION: Bladder tumors of cattle are very uncommon accounting from 0.1% to 0.01% of all bovine malignancies. Bladder tumors are common in cattle grazing on bracken fern-infested pasturelands. Bovine papillomaviruses have a crucial role in tumors of bovine urinary bladder. AIM OF THE STUDY: To investigate the potential association of ovine papillomavirus (OaPV) infection with bladder carcinogenesis of cattle. METHODS: Droplet digital PCR was used to detect and quantify the nucleic acids of OaPVs in bladder tumors of cattle that were collected at public and private slaughterhouses. RESULTS: OaPV DNA and RNA were detected and quantified in 10 bladder tumors of cattle that were tested negative for bovine papillomaviruses. The most prevalent genotypes were OaPV1 and OaPV2. OaPV4 was rarely observed. Furthermore, we detected a significant overexpression and hyperphosphorylation of pRb and a significant overexpression and activation of the calpain-1 as well as a significant overexpression of E2F3 and of phosphorylated (activated) PDGFβR in neoplastic bladders in comparison with healthy bladders, which suggests that E2F3 and PDGFβR may play an important role in OaPV-mediated molecular pathways that lead to bladder carcinogenesis. CONCLUSION: In all tumors, OaPV RNA could explain the causality of the disease of the urinary bladder. Therefore, persistent infections by OaPVs could be involved in bladder carcinogenesis. Our data showed that there is a possible etiologic association of OaPVs with bladder tumors of cattle.
format Online
Article
Text
id pubmed-10194246
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-101942462023-05-19 Possible etiological association of ovine papillomaviruses with bladder tumors in cattle De Falco, Francesca Cuccaro, Bianca De Tullio, Roberta Alberti, Alberto Cutarelli, Anna De Carlo, Esterina Roperto, Sante Virus Res Review INTRODUCTION: Bladder tumors of cattle are very uncommon accounting from 0.1% to 0.01% of all bovine malignancies. Bladder tumors are common in cattle grazing on bracken fern-infested pasturelands. Bovine papillomaviruses have a crucial role in tumors of bovine urinary bladder. AIM OF THE STUDY: To investigate the potential association of ovine papillomavirus (OaPV) infection with bladder carcinogenesis of cattle. METHODS: Droplet digital PCR was used to detect and quantify the nucleic acids of OaPVs in bladder tumors of cattle that were collected at public and private slaughterhouses. RESULTS: OaPV DNA and RNA were detected and quantified in 10 bladder tumors of cattle that were tested negative for bovine papillomaviruses. The most prevalent genotypes were OaPV1 and OaPV2. OaPV4 was rarely observed. Furthermore, we detected a significant overexpression and hyperphosphorylation of pRb and a significant overexpression and activation of the calpain-1 as well as a significant overexpression of E2F3 and of phosphorylated (activated) PDGFβR in neoplastic bladders in comparison with healthy bladders, which suggests that E2F3 and PDGFβR may play an important role in OaPV-mediated molecular pathways that lead to bladder carcinogenesis. CONCLUSION: In all tumors, OaPV RNA could explain the causality of the disease of the urinary bladder. Therefore, persistent infections by OaPVs could be involved in bladder carcinogenesis. Our data showed that there is a possible etiologic association of OaPVs with bladder tumors of cattle. Elsevier 2023-03-06 /pmc/articles/PMC10194246/ /pubmed/36878382 http://dx.doi.org/10.1016/j.virusres.2023.199084 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
De Falco, Francesca
Cuccaro, Bianca
De Tullio, Roberta
Alberti, Alberto
Cutarelli, Anna
De Carlo, Esterina
Roperto, Sante
Possible etiological association of ovine papillomaviruses with bladder tumors in cattle
title Possible etiological association of ovine papillomaviruses with bladder tumors in cattle
title_full Possible etiological association of ovine papillomaviruses with bladder tumors in cattle
title_fullStr Possible etiological association of ovine papillomaviruses with bladder tumors in cattle
title_full_unstemmed Possible etiological association of ovine papillomaviruses with bladder tumors in cattle
title_short Possible etiological association of ovine papillomaviruses with bladder tumors in cattle
title_sort possible etiological association of ovine papillomaviruses with bladder tumors in cattle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194246/
https://www.ncbi.nlm.nih.gov/pubmed/36878382
http://dx.doi.org/10.1016/j.virusres.2023.199084
work_keys_str_mv AT defalcofrancesca possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle
AT cuccarobianca possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle
AT detullioroberta possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle
AT albertialberto possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle
AT cutarellianna possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle
AT decarloesterina possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle
AT ropertosante possibleetiologicalassociationofovinepapillomaviruseswithbladdertumorsincattle