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Complete deletion of Ectromelia virus p28 impairs virus genome replication in a mouse strain, cell type, and multiplicity of infection-dependent manner

p28 is a poxvirus-encoded E3 ubiquitin ligase that possesses an N-terminal KilA-N domain and a C-terminal RING domain. In Ectromelia virus (ECTV), disruption of the p28 RING domain severely attenuated virulence in A strain mice, which normally succumb to ECTV infection. Moreover, this mutant virus e...

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Detalles Bibliográficos
Autores principales:	Dong, Jianing, Paszkowski, Patrick, Kocincova, Dana, Ingham, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194247/ https://www.ncbi.nlm.nih.gov/pubmed/36244618 http://dx.doi.org/10.1016/j.virusres.2022.198968

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