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Exploring antibiotic resistance with chemical tools

Antibiotic resistance is an enormous problem that is accountable for over a million deaths annually, with numbers expected to significantly increase over the coming decades. Although some of the underlying causes leading up to antibiotic resistance are well understood, many of the molecular processe...

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Autor principal: Velema, Willem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194278/
https://www.ncbi.nlm.nih.gov/pubmed/37039397
http://dx.doi.org/10.1039/d3cc00759f
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author Velema, Willem A.
author_facet Velema, Willem A.
author_sort Velema, Willem A.
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description Antibiotic resistance is an enormous problem that is accountable for over a million deaths annually, with numbers expected to significantly increase over the coming decades. Although some of the underlying causes leading up to antibiotic resistance are well understood, many of the molecular processes involved remain elusive. To better appreciate at a molecular level how resistance emerges, customized chemical biology tools can offer a solution. This Feature Article attempts to provide an overview of the wide variety of tools that have been developed over the last decade, by highlighting some of the more illustrative examples. These include the use of fluorescent, photoaffinity and activatable antibiotics and bacterial components to start to unravel the molecular mechanisms involved in resistance. The antibiotic crisis is an eminent global threat and requires the continuous development of creative chemical tools to dissect and ultimately counteract resistance.
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spelling pubmed-101942782023-05-19 Exploring antibiotic resistance with chemical tools Velema, Willem A. Chem Commun (Camb) Chemistry Antibiotic resistance is an enormous problem that is accountable for over a million deaths annually, with numbers expected to significantly increase over the coming decades. Although some of the underlying causes leading up to antibiotic resistance are well understood, many of the molecular processes involved remain elusive. To better appreciate at a molecular level how resistance emerges, customized chemical biology tools can offer a solution. This Feature Article attempts to provide an overview of the wide variety of tools that have been developed over the last decade, by highlighting some of the more illustrative examples. These include the use of fluorescent, photoaffinity and activatable antibiotics and bacterial components to start to unravel the molecular mechanisms involved in resistance. The antibiotic crisis is an eminent global threat and requires the continuous development of creative chemical tools to dissect and ultimately counteract resistance. The Royal Society of Chemistry 2023-04-05 /pmc/articles/PMC10194278/ /pubmed/37039397 http://dx.doi.org/10.1039/d3cc00759f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Velema, Willem A.
Exploring antibiotic resistance with chemical tools
title Exploring antibiotic resistance with chemical tools
title_full Exploring antibiotic resistance with chemical tools
title_fullStr Exploring antibiotic resistance with chemical tools
title_full_unstemmed Exploring antibiotic resistance with chemical tools
title_short Exploring antibiotic resistance with chemical tools
title_sort exploring antibiotic resistance with chemical tools
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194278/
https://www.ncbi.nlm.nih.gov/pubmed/37039397
http://dx.doi.org/10.1039/d3cc00759f
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