Cargando…
Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?
Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of po...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194709/ https://www.ncbi.nlm.nih.gov/pubmed/37335735 http://dx.doi.org/10.1097/MD.0000000000033757 |
_version_ | 1785044071789625344 |
---|---|
author | Çapkinoğlu, Emir Tufan, Aydin Eray Ömeroğlu, Sinan Tanal, Mert Güven, Onur Demir, Uygar |
author_facet | Çapkinoğlu, Emir Tufan, Aydin Eray Ömeroğlu, Sinan Tanal, Mert Güven, Onur Demir, Uygar |
author_sort | Çapkinoğlu, Emir |
collection | PubMed |
description | Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of positive lymph nodes after a pathological examination following the surgical intervention is of prognostic value. In this study, it is aimed to evaluate the prognostic significance of positive lymph nodes following the surgery. A total of 193 patients who underwent curative gastrectomy between January 2011 and December 2015 have been considered for a retrospective data collection. The cases with R1-R2 resections, palliative or emergent surgeries are excluded. Metastatic to total number of lymph nodes, corresponded a ratio which was analyzed in this survey and practiced as a predictive parameter of disease outcome. This survey includes 138 male (71.5%) and 55 female (28.5%) patients treated between 2011 and 2015 in our clinic. The survey follow-up duration of the cases range between 0, 2, and 72 months, corresponding an average of 23.24 ± 16.99 months. We calculated cutoff value of 0.09 with, sensitivity is 76.32% for positive to total number of lymph nodes ratio, whereas specivity applies for 64.10%, positive predictive value for 58% and negative predictive value for 80.6%. Positive lymph node ratio has a prognostic value in terms of predicting the prognosis of the patients with gastric adenocarcinoma following a curative gastrectomy. This might in long term contribute to the prognostic analysis of patients if integrated in the current staging system. |
format | Online Article Text |
id | pubmed-10194709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101947092023-05-19 Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? Çapkinoğlu, Emir Tufan, Aydin Eray Ömeroğlu, Sinan Tanal, Mert Güven, Onur Demir, Uygar Medicine (Baltimore) 7100 Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of positive lymph nodes after a pathological examination following the surgical intervention is of prognostic value. In this study, it is aimed to evaluate the prognostic significance of positive lymph nodes following the surgery. A total of 193 patients who underwent curative gastrectomy between January 2011 and December 2015 have been considered for a retrospective data collection. The cases with R1-R2 resections, palliative or emergent surgeries are excluded. Metastatic to total number of lymph nodes, corresponded a ratio which was analyzed in this survey and practiced as a predictive parameter of disease outcome. This survey includes 138 male (71.5%) and 55 female (28.5%) patients treated between 2011 and 2015 in our clinic. The survey follow-up duration of the cases range between 0, 2, and 72 months, corresponding an average of 23.24 ± 16.99 months. We calculated cutoff value of 0.09 with, sensitivity is 76.32% for positive to total number of lymph nodes ratio, whereas specivity applies for 64.10%, positive predictive value for 58% and negative predictive value for 80.6%. Positive lymph node ratio has a prognostic value in terms of predicting the prognosis of the patients with gastric adenocarcinoma following a curative gastrectomy. This might in long term contribute to the prognostic analysis of patients if integrated in the current staging system. Lippincott Williams & Wilkins 2023-05-17 /pmc/articles/PMC10194709/ /pubmed/37335735 http://dx.doi.org/10.1097/MD.0000000000033757 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 7100 Çapkinoğlu, Emir Tufan, Aydin Eray Ömeroğlu, Sinan Tanal, Mert Güven, Onur Demir, Uygar Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? |
title | Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? |
title_full | Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? |
title_fullStr | Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? |
title_full_unstemmed | Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? |
title_short | Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines? |
title_sort | positive lymph node ratio as a prognostic factor for gastric cancer patients: is it going to supersede positive lymph node number in guidelines? |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194709/ https://www.ncbi.nlm.nih.gov/pubmed/37335735 http://dx.doi.org/10.1097/MD.0000000000033757 |
work_keys_str_mv | AT capkinogluemir positivelymphnoderatioasaprognosticfactorforgastriccancerpatientsisitgoingtosupersedepositivelymphnodenumberinguidelines AT tufanaydineray positivelymphnoderatioasaprognosticfactorforgastriccancerpatientsisitgoingtosupersedepositivelymphnodenumberinguidelines AT omeroglusinan positivelymphnoderatioasaprognosticfactorforgastriccancerpatientsisitgoingtosupersedepositivelymphnodenumberinguidelines AT tanalmert positivelymphnoderatioasaprognosticfactorforgastriccancerpatientsisitgoingtosupersedepositivelymphnodenumberinguidelines AT guvenonur positivelymphnoderatioasaprognosticfactorforgastriccancerpatientsisitgoingtosupersedepositivelymphnodenumberinguidelines AT demiruygar positivelymphnoderatioasaprognosticfactorforgastriccancerpatientsisitgoingtosupersedepositivelymphnodenumberinguidelines |