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Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition

Ubiquitin-conjugating enzyme E2C (UBE2C), its overexpression promotes tumor progression, is a key component of the ubiquitin conjugating proteasome complex. Epithelial-mesenchymal transition, which is lost epithelial features and gained mesenchymal features in some epithelial cancers, is involved in...

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Autores principales: Zhang, Yan, Li, Xueting, Gong, Yingying, Du, Danli, Chen, Huilei, Liu, Lei, Cheng, Zenong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194742/
https://www.ncbi.nlm.nih.gov/pubmed/37335710
http://dx.doi.org/10.1097/MD.0000000000033834
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author Zhang, Yan
Li, Xueting
Gong, Yingying
Du, Danli
Chen, Huilei
Liu, Lei
Cheng, Zenong
author_facet Zhang, Yan
Li, Xueting
Gong, Yingying
Du, Danli
Chen, Huilei
Liu, Lei
Cheng, Zenong
author_sort Zhang, Yan
collection PubMed
description Ubiquitin-conjugating enzyme E2C (UBE2C), its overexpression promotes tumor progression, is a key component of the ubiquitin conjugating proteasome complex. Epithelial-mesenchymal transition, which is lost epithelial features and gained mesenchymal features in some epithelial cancers, is involved in epithelial cancers’ invasiveness and metastasis. The aim of this study is to detect the expression of UBE2C, WNT5α, and E-cad in endometrial cancer (EC) and their clinical significance. The expression of UBE2C, WNT5α, and ZEB1 in 125 cases EC tissues were detected by immunohistochemistry. Patients clinicopathological, demography, and follow-up data were also collected. Positive rates of expression of UBE2C and ZEB1 were significantly higher in EC tissues when compared with the control tissues. The positive expression of UBE2C and ZEB1 were positively associated with tumor stages, local lymph node metastasis, and International Federation of Gynecology and Obstetrics (FIGO) stages. The positive rate of expression of WNT5a was significantly lower in EC tissues when compared with the control tissues. And positive expression of E-cad was inversely related to tumor stages, lymph node metastasis stages, and FIGO stages. Kaplan–Meier analyses demonstrated that positive expression of UBE2C or ZEB1 for EC patients had unfavorably overall survival time when compared with patients with negative expression of UBE2C or ZEB1. And EC patients with positive expression of WNT5a had favorably overall survival time when compared with EC patients with negative expression of WNT5a. Multivariate analysis demonstrated that positive expression UBE2C, WNT5α, and ZEB1, as well as FIGO stages were independent prognostic factors for EC patients. UBE2C, ZEB1, and WNT5a should be considered promising biomarkers for EC patients’ prognosis.
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spelling pubmed-101947422023-05-19 Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition Zhang, Yan Li, Xueting Gong, Yingying Du, Danli Chen, Huilei Liu, Lei Cheng, Zenong Medicine (Baltimore) 5600 Ubiquitin-conjugating enzyme E2C (UBE2C), its overexpression promotes tumor progression, is a key component of the ubiquitin conjugating proteasome complex. Epithelial-mesenchymal transition, which is lost epithelial features and gained mesenchymal features in some epithelial cancers, is involved in epithelial cancers’ invasiveness and metastasis. The aim of this study is to detect the expression of UBE2C, WNT5α, and E-cad in endometrial cancer (EC) and their clinical significance. The expression of UBE2C, WNT5α, and ZEB1 in 125 cases EC tissues were detected by immunohistochemistry. Patients clinicopathological, demography, and follow-up data were also collected. Positive rates of expression of UBE2C and ZEB1 were significantly higher in EC tissues when compared with the control tissues. The positive expression of UBE2C and ZEB1 were positively associated with tumor stages, local lymph node metastasis, and International Federation of Gynecology and Obstetrics (FIGO) stages. The positive rate of expression of WNT5a was significantly lower in EC tissues when compared with the control tissues. And positive expression of E-cad was inversely related to tumor stages, lymph node metastasis stages, and FIGO stages. Kaplan–Meier analyses demonstrated that positive expression of UBE2C or ZEB1 for EC patients had unfavorably overall survival time when compared with patients with negative expression of UBE2C or ZEB1. And EC patients with positive expression of WNT5a had favorably overall survival time when compared with EC patients with negative expression of WNT5a. Multivariate analysis demonstrated that positive expression UBE2C, WNT5α, and ZEB1, as well as FIGO stages were independent prognostic factors for EC patients. UBE2C, ZEB1, and WNT5a should be considered promising biomarkers for EC patients’ prognosis. Lippincott Williams & Wilkins 2023-05-17 /pmc/articles/PMC10194742/ /pubmed/37335710 http://dx.doi.org/10.1097/MD.0000000000033834 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5600
Zhang, Yan
Li, Xueting
Gong, Yingying
Du, Danli
Chen, Huilei
Liu, Lei
Cheng, Zenong
Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition
title Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition
title_full Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition
title_fullStr Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition
title_full_unstemmed Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition
title_short Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition
title_sort aberrant expression of ube2c in endometrial cancer and its correlation to epithelial mesenchymal transition
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194742/
https://www.ncbi.nlm.nih.gov/pubmed/37335710
http://dx.doi.org/10.1097/MD.0000000000033834
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