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The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis
Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients face several hematological abnormalities. Of these abnormalities, anemia is the most common one. Africa has a high prevalence of HIV/AIDS, especially in the East and South African region, which is heavily affected...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194790/ https://www.ncbi.nlm.nih.gov/pubmed/37335739 http://dx.doi.org/10.1097/MD.0000000000033810 |
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author | Getu, Fasil Aynalem, Melak Walle, Muluken Enawgaw, Bamlaku |
author_facet | Getu, Fasil Aynalem, Melak Walle, Muluken Enawgaw, Bamlaku |
author_sort | Getu, Fasil |
collection | PubMed |
description | Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients face several hematological abnormalities. Of these abnormalities, anemia is the most common one. Africa has a high prevalence of HIV/AIDS, especially in the East and South African region, which is heavily affected by the virus. Therefore, this systematic review and meta-analysis aimed to determine the pooled prevalence of anemia among patients with HIV/AIDS in East Africa. METHODS: This systematic review and meta-analysis was conducted based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. PubMed, Google Scholar, Science Direct, Dove Press, Cochrane Online, and African journals online were searched systematically. The quality of the included studies was assessed by 2 independent reviewers using the Joanna Briggs Institute critical appraisal tools. Data were extracted into an Excel sheet and then exported to STATA version 11 for analysis. A random-effect model was fitted to estimate the pooled prevalence and Higgins I(2) test statistics were done to test the heterogeneity of studies. Funnel plots analysis and Egger-weighted regression tests were done to detect publication bias. RESULTS: The pooled prevalence of anemia among HIV/AIDS patients in East Africa was 25.35% (95% CI: 20.69–30.03%). A subgroup analysis by highly active antiretroviral therapy (HAART) status showed that the prevalence of anemia among HAART naive HIV/AIDS patients was 39.11% (95% CI: 29.28–48.93%) whereas the prevalence among HAART experienced was 36.72% (95% CI: 31.22–42.22%). A subgroup analysis by the study population showed that the prevalence of anemia among adult HIV/AIDS patients was 34.48% (95% CI: 29.52–39.44%) whereas the pooled prevalence among children was 36.17% (95% CI: 26.68–45.65%). CONCLUSION: This systematic review and meta-analysis revealed that anemia is among the most common hematological abnormalities in HIV/AIDS patients in East Africa. It also underscored the importance of taking diagnostic, preventive, and therapeutic measures for the management of this abnormality. |
format | Online Article Text |
id | pubmed-10194790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101947902023-05-19 The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis Getu, Fasil Aynalem, Melak Walle, Muluken Enawgaw, Bamlaku Medicine (Baltimore) 4850 Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients face several hematological abnormalities. Of these abnormalities, anemia is the most common one. Africa has a high prevalence of HIV/AIDS, especially in the East and South African region, which is heavily affected by the virus. Therefore, this systematic review and meta-analysis aimed to determine the pooled prevalence of anemia among patients with HIV/AIDS in East Africa. METHODS: This systematic review and meta-analysis was conducted based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. PubMed, Google Scholar, Science Direct, Dove Press, Cochrane Online, and African journals online were searched systematically. The quality of the included studies was assessed by 2 independent reviewers using the Joanna Briggs Institute critical appraisal tools. Data were extracted into an Excel sheet and then exported to STATA version 11 for analysis. A random-effect model was fitted to estimate the pooled prevalence and Higgins I(2) test statistics were done to test the heterogeneity of studies. Funnel plots analysis and Egger-weighted regression tests were done to detect publication bias. RESULTS: The pooled prevalence of anemia among HIV/AIDS patients in East Africa was 25.35% (95% CI: 20.69–30.03%). A subgroup analysis by highly active antiretroviral therapy (HAART) status showed that the prevalence of anemia among HAART naive HIV/AIDS patients was 39.11% (95% CI: 29.28–48.93%) whereas the prevalence among HAART experienced was 36.72% (95% CI: 31.22–42.22%). A subgroup analysis by the study population showed that the prevalence of anemia among adult HIV/AIDS patients was 34.48% (95% CI: 29.52–39.44%) whereas the pooled prevalence among children was 36.17% (95% CI: 26.68–45.65%). CONCLUSION: This systematic review and meta-analysis revealed that anemia is among the most common hematological abnormalities in HIV/AIDS patients in East Africa. It also underscored the importance of taking diagnostic, preventive, and therapeutic measures for the management of this abnormality. Lippincott Williams & Wilkins 2023-05-17 /pmc/articles/PMC10194790/ /pubmed/37335739 http://dx.doi.org/10.1097/MD.0000000000033810 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 4850 Getu, Fasil Aynalem, Melak Walle, Muluken Enawgaw, Bamlaku The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis |
title | The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis |
title_full | The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis |
title_fullStr | The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis |
title_full_unstemmed | The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis |
title_short | The prevalence of anemia among human immunodeficiency virus-infected individuals in East Africa: A systematic review and meta-analysis |
title_sort | prevalence of anemia among human immunodeficiency virus-infected individuals in east africa: a systematic review and meta-analysis |
topic | 4850 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194790/ https://www.ncbi.nlm.nih.gov/pubmed/37335739 http://dx.doi.org/10.1097/MD.0000000000033810 |
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