Unmasking a fungal fire

Immune checkpoint inhibitor (ICI) therapy represents a breakthrough cancer treatment by stimulating dysfunctional T cells in the tumour environment to kill cancer cells. Beyond effects on anticancer immunity, ICI therapy may be associated with increased susceptibility to or more rapid resolution of...

Descripción completa

Detalles Bibliográficos
Autores principales: Dambuza, Ivy M., Warris, Adilia, Salazar, Fabián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Pearls
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194863/
https://www.ncbi.nlm.nih.gov/pubmed/37200244
http://dx.doi.org/10.1371/journal.ppat.1011355
Descripción
Sumario:Immune checkpoint inhibitor (ICI) therapy represents a breakthrough cancer treatment by stimulating dysfunctional T cells in the tumour environment to kill cancer cells. Beyond effects on anticancer immunity, ICI therapy may be associated with increased susceptibility to or more rapid resolution of chronic infections, particularly those caused by human fungal pathogens. In this concise review, we summarise recent observations and findings that implicate immune checkpoint blockade in fungal infection outcomes.

Ejemplares similares