Unmasking a fungal fire

Immune checkpoint inhibitor (ICI) therapy represents a breakthrough cancer treatment by stimulating dysfunctional T cells in the tumour environment to kill cancer cells. Beyond effects on anticancer immunity, ICI therapy may be associated with increased susceptibility to or more rapid resolution of...

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Detalles Bibliográficos
Autores principales: Dambuza, Ivy M., Warris, Adilia, Salazar, Fabián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Pearls
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194863/
https://www.ncbi.nlm.nih.gov/pubmed/37200244
http://dx.doi.org/10.1371/journal.ppat.1011355
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author Dambuza, Ivy M.
Warris, Adilia
Salazar, Fabián
author_facet Dambuza, Ivy M.
Warris, Adilia
Salazar, Fabián
author_sort Dambuza, Ivy M.
collection PubMed
description Immune checkpoint inhibitor (ICI) therapy represents a breakthrough cancer treatment by stimulating dysfunctional T cells in the tumour environment to kill cancer cells. Beyond effects on anticancer immunity, ICI therapy may be associated with increased susceptibility to or more rapid resolution of chronic infections, particularly those caused by human fungal pathogens. In this concise review, we summarise recent observations and findings that implicate immune checkpoint blockade in fungal infection outcomes.
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spelling pubmed-101948632023-05-19 Unmasking a fungal fire Dambuza, Ivy M. Warris, Adilia Salazar, Fabián PLoS Pathog Pearls Immune checkpoint inhibitor (ICI) therapy represents a breakthrough cancer treatment by stimulating dysfunctional T cells in the tumour environment to kill cancer cells. Beyond effects on anticancer immunity, ICI therapy may be associated with increased susceptibility to or more rapid resolution of chronic infections, particularly those caused by human fungal pathogens. In this concise review, we summarise recent observations and findings that implicate immune checkpoint blockade in fungal infection outcomes. Public Library of Science 2023-05-18 /pmc/articles/PMC10194863/ /pubmed/37200244 http://dx.doi.org/10.1371/journal.ppat.1011355 Text en © 2023 Dambuza et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pearls
Dambuza, Ivy M.
Warris, Adilia
Salazar, Fabián
Unmasking a fungal fire
title Unmasking a fungal fire
title_full Unmasking a fungal fire
title_fullStr Unmasking a fungal fire
title_full_unstemmed Unmasking a fungal fire
title_short Unmasking a fungal fire
title_sort unmasking a fungal fire
topic Pearls
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194863/
https://www.ncbi.nlm.nih.gov/pubmed/37200244
http://dx.doi.org/10.1371/journal.ppat.1011355
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