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Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019

Chikungunya is an arboviral disease causing arthralgia which may develop into a debilitating chronic arthritis. In Mayotte, a French overseas department in the Indian Ocean, a chikungunya outbreak was reported in 2006, affecting a third of the population. We aimed at assessing the chikungunya seropr...

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Autores principales: Ortu, Giuseppina, Grard, Gilda, Parenton, Fanny, Ruello, Marc, Paty, Marie-Claire, Durand, Guillaume André, Hassani, Youssouf, De Valk, Henriette, Noël, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194921/
https://www.ncbi.nlm.nih.gov/pubmed/37200250
http://dx.doi.org/10.1371/journal.pone.0285879
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author Ortu, Giuseppina
Grard, Gilda
Parenton, Fanny
Ruello, Marc
Paty, Marie-Claire
Durand, Guillaume André
Hassani, Youssouf
De Valk, Henriette
Noël, Harold
author_facet Ortu, Giuseppina
Grard, Gilda
Parenton, Fanny
Ruello, Marc
Paty, Marie-Claire
Durand, Guillaume André
Hassani, Youssouf
De Valk, Henriette
Noël, Harold
author_sort Ortu, Giuseppina
collection PubMed
description Chikungunya is an arboviral disease causing arthralgia which may develop into a debilitating chronic arthritis. In Mayotte, a French overseas department in the Indian Ocean, a chikungunya outbreak was reported in 2006, affecting a third of the population. We aimed at assessing the chikungunya seroprevalence in this population, after over a decade from that epidemic. A multi-stage cross sectional household-based study exploring socio-demographic factors, and knowledge and attitude towards mosquito-borne disease prevention was carried out in 2019. Blood samples from participants aged 15–69 years were taken for chikungunya IgG serological testing. We analyzed associations between chikungunya serological status and selected factors using Poisson regression models, and estimated weighted and adjusted prevalence ratios (w/a PR). The weighted seroprevalence of chikungunya was 34.75% (n = 2853). Seropositivity for IgG anti-chikungunya virus was found associated with living in Mamoudzou (w/a PR = 1.49, 95%CI: 1.21–1.83) and North (w/a PR = 1.41, 95%CI: 1.08–1.84) sectors, being born in the Comoros islands (w/a PR = 1.30, 95%CI: 1.03–1.61), being a student or unpaid trainee (w/a PR = 1.35, 95%CI: 1.01–1.81), living in precarious housing (w/a PR = 1.30, 95%CI: 1.02–1.67), accessing water streams for bathing (w/a PR = 1.72, 95%CI: 1.1–2.7) and knowing that malaria is a mosquito-borne disease (w/a PR = 1.42, 95%CI: 1.21–1.83). Seropositivity was found inversely associated with high education level (w/a PR = 0.50, 95%CI: 0.29–0.86) and living in households with access to running water and toilets (w/a PR = 0.64, 95%CI: 0.51–0.80) (n = 1438). Our results indicate a long-lasting immunity from chikungunya exposure. However, the current population seroprevalence is not enough to protect from future outbreaks. Individuals naïve to chikungunya and living in precarious socio-economic conditions are likely to be at high risk of infection in future outbreaks. To prevent and prepare for future chikungunya epidemics, it is essential to address socio-economic inequalities as a priority, and to strengthen chikungunya surveillance in Mayotte.
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spelling pubmed-101949212023-05-19 Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019 Ortu, Giuseppina Grard, Gilda Parenton, Fanny Ruello, Marc Paty, Marie-Claire Durand, Guillaume André Hassani, Youssouf De Valk, Henriette Noël, Harold PLoS One Research Article Chikungunya is an arboviral disease causing arthralgia which may develop into a debilitating chronic arthritis. In Mayotte, a French overseas department in the Indian Ocean, a chikungunya outbreak was reported in 2006, affecting a third of the population. We aimed at assessing the chikungunya seroprevalence in this population, after over a decade from that epidemic. A multi-stage cross sectional household-based study exploring socio-demographic factors, and knowledge and attitude towards mosquito-borne disease prevention was carried out in 2019. Blood samples from participants aged 15–69 years were taken for chikungunya IgG serological testing. We analyzed associations between chikungunya serological status and selected factors using Poisson regression models, and estimated weighted and adjusted prevalence ratios (w/a PR). The weighted seroprevalence of chikungunya was 34.75% (n = 2853). Seropositivity for IgG anti-chikungunya virus was found associated with living in Mamoudzou (w/a PR = 1.49, 95%CI: 1.21–1.83) and North (w/a PR = 1.41, 95%CI: 1.08–1.84) sectors, being born in the Comoros islands (w/a PR = 1.30, 95%CI: 1.03–1.61), being a student or unpaid trainee (w/a PR = 1.35, 95%CI: 1.01–1.81), living in precarious housing (w/a PR = 1.30, 95%CI: 1.02–1.67), accessing water streams for bathing (w/a PR = 1.72, 95%CI: 1.1–2.7) and knowing that malaria is a mosquito-borne disease (w/a PR = 1.42, 95%CI: 1.21–1.83). Seropositivity was found inversely associated with high education level (w/a PR = 0.50, 95%CI: 0.29–0.86) and living in households with access to running water and toilets (w/a PR = 0.64, 95%CI: 0.51–0.80) (n = 1438). Our results indicate a long-lasting immunity from chikungunya exposure. However, the current population seroprevalence is not enough to protect from future outbreaks. Individuals naïve to chikungunya and living in precarious socio-economic conditions are likely to be at high risk of infection in future outbreaks. To prevent and prepare for future chikungunya epidemics, it is essential to address socio-economic inequalities as a priority, and to strengthen chikungunya surveillance in Mayotte. Public Library of Science 2023-05-18 /pmc/articles/PMC10194921/ /pubmed/37200250 http://dx.doi.org/10.1371/journal.pone.0285879 Text en © 2023 Ortu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ortu, Giuseppina
Grard, Gilda
Parenton, Fanny
Ruello, Marc
Paty, Marie-Claire
Durand, Guillaume André
Hassani, Youssouf
De Valk, Henriette
Noël, Harold
Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019
title Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019
title_full Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019
title_fullStr Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019
title_full_unstemmed Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019
title_short Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019
title_sort long lasting anti-igg chikungunya seropositivity in the mayotte population will not be enough to prevent future outbreaks: a seroprevalence study, 2019
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194921/
https://www.ncbi.nlm.nih.gov/pubmed/37200250
http://dx.doi.org/10.1371/journal.pone.0285879
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