Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody

Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fcγ receptors, thereby dictating distinct cellular responses....

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Detalles Bibliográficos
Autores principales: Gupta, Aaron, Kao, Kevin S., Yamin, Rachel, Oren, Deena A., Goldgur, Yehuda, Du, Jonathan, Lollar, Pete, Sundberg, Eric J., Ravetch, Jeffrey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195009/
https://www.ncbi.nlm.nih.gov/pubmed/37202422
http://dx.doi.org/10.1038/s41467-023-38453-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195009/
https://www.ncbi.nlm.nih.gov/pubmed/37202422
http://dx.doi.org/10.1038/s41467-023-38453-1

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