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Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody
Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fcγ receptors, thereby dictating distinct cellular responses....
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195009/ https://www.ncbi.nlm.nih.gov/pubmed/37202422 http://dx.doi.org/10.1038/s41467-023-38453-1 |