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Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice

PURPOSE: Previous reports showed that some probiotics provide beneficial effects on various diseases including metabolic disorders. This study aimed to investigate the anti-obesity effects of Lactiplantibacillus (L.) plantarum SKO-001 (SKO-001), a probiotic strain newly isolated from Angelica gigas....

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Autores principales: Choi, Mi Jin, Yu, Hana, Kim, Jea Il, Seo, Hee, Kim, Ju Gyeong, Kim, Seul-Ki, Lee, Hak Sung, Cheon, Hyae Gyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195764/
https://www.ncbi.nlm.nih.gov/pubmed/36729332
http://dx.doi.org/10.1007/s00394-023-03096-x
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author Choi, Mi Jin
Yu, Hana
Kim, Jea Il
Seo, Hee
Kim, Ju Gyeong
Kim, Seul-Ki
Lee, Hak Sung
Cheon, Hyae Gyeong
author_facet Choi, Mi Jin
Yu, Hana
Kim, Jea Il
Seo, Hee
Kim, Ju Gyeong
Kim, Seul-Ki
Lee, Hak Sung
Cheon, Hyae Gyeong
author_sort Choi, Mi Jin
collection PubMed
description PURPOSE: Previous reports showed that some probiotics provide beneficial effects on various diseases including metabolic disorders. This study aimed to investigate the anti-obesity effects of Lactiplantibacillus (L.) plantarum SKO-001 (SKO-001), a probiotic strain newly isolated from Angelica gigas. METHODS: C57BL/6J mice were fed with high-fat diet (HFD, 60% fat) for four weeks, and then different doses of SKO-001 (n = 10 each group) were orally given for 12 weeks. Following treatment, body weight, fat weight, serum parameters and adipose and liver tissues were analyzed. RESULTS: SKO-001 (2 × 10(10) CFU/day, per os) reduced body weight gain after 10th week of administration, accompanied by a reduction in body fat mass of mice. In the SKO-001-fed group, increased serum adiponectin, decreased leptin, insulin, total cholesterol, low-density lipoprotein cholesterol, free fatty acids, and triglyceride levels were observed. Hematoxylin and eosin staining of various fat depots showed that increased adipocyte size caused by HFD intake was markedly reduced and correlated with reduced mRNA levels of lipogenesis genes, including sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and CCAAT/enhancer binding protein alpha, and increased uncoupling protein 1 levels. Similarly, SKO-001 reduced lipid accumulation, decreased the mRNA levels of lipogenic genes, and reduced α-smooth muscle actin and collagen type 1 alpha 1 levels in the liver. CONCLUSIONS: SKO-001 ameliorates obesity and related metabolic abnormalities in adipose and liver tissues, possibly via the regulation of lipid metabolism. Based on the results of the present study, SKO-001 may be applicable as an anti-obesity therapeutic or functional food. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03096-x.
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spelling pubmed-101957642023-05-20 Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice Choi, Mi Jin Yu, Hana Kim, Jea Il Seo, Hee Kim, Ju Gyeong Kim, Seul-Ki Lee, Hak Sung Cheon, Hyae Gyeong Eur J Nutr Original Contribution PURPOSE: Previous reports showed that some probiotics provide beneficial effects on various diseases including metabolic disorders. This study aimed to investigate the anti-obesity effects of Lactiplantibacillus (L.) plantarum SKO-001 (SKO-001), a probiotic strain newly isolated from Angelica gigas. METHODS: C57BL/6J mice were fed with high-fat diet (HFD, 60% fat) for four weeks, and then different doses of SKO-001 (n = 10 each group) were orally given for 12 weeks. Following treatment, body weight, fat weight, serum parameters and adipose and liver tissues were analyzed. RESULTS: SKO-001 (2 × 10(10) CFU/day, per os) reduced body weight gain after 10th week of administration, accompanied by a reduction in body fat mass of mice. In the SKO-001-fed group, increased serum adiponectin, decreased leptin, insulin, total cholesterol, low-density lipoprotein cholesterol, free fatty acids, and triglyceride levels were observed. Hematoxylin and eosin staining of various fat depots showed that increased adipocyte size caused by HFD intake was markedly reduced and correlated with reduced mRNA levels of lipogenesis genes, including sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and CCAAT/enhancer binding protein alpha, and increased uncoupling protein 1 levels. Similarly, SKO-001 reduced lipid accumulation, decreased the mRNA levels of lipogenic genes, and reduced α-smooth muscle actin and collagen type 1 alpha 1 levels in the liver. CONCLUSIONS: SKO-001 ameliorates obesity and related metabolic abnormalities in adipose and liver tissues, possibly via the regulation of lipid metabolism. Based on the results of the present study, SKO-001 may be applicable as an anti-obesity therapeutic or functional food. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03096-x. Springer Berlin Heidelberg 2023-02-02 2023 /pmc/articles/PMC10195764/ /pubmed/36729332 http://dx.doi.org/10.1007/s00394-023-03096-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
Choi, Mi Jin
Yu, Hana
Kim, Jea Il
Seo, Hee
Kim, Ju Gyeong
Kim, Seul-Ki
Lee, Hak Sung
Cheon, Hyae Gyeong
Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
title Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
title_full Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
title_fullStr Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
title_full_unstemmed Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
title_short Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
title_sort anti-obesity effects of lactiplantibacillus plantarum sko-001 in high-fat diet-induced obese mice
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195764/
https://www.ncbi.nlm.nih.gov/pubmed/36729332
http://dx.doi.org/10.1007/s00394-023-03096-x
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