FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth

Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 is a highly mutated gene in CRC, but its biological functions in cancer are not fully characterized. Here, we report that FBXW7β, a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC, i...

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Detalles Bibliográficos
Autores principales: Wei, Wenxia, Qin, Baifu, Wen, Weijie, Zhang, Boyu, Luo, Haidan, Wang, Yuzhi, Xu, Hui, Xie, Xiaoshan, Liu, Sicheng, Jiang, Xin, Wang, Mengan, Tang, Qin, Zhang, Jiayu, Yang, Runxiang, Fan, Zongmin, Lyu, Haiwen, Lin, Junzhong, Li, Kai, Lee, Mong-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195794/
https://www.ncbi.nlm.nih.gov/pubmed/37202390
http://dx.doi.org/10.1038/s41392-023-01405-8

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