Cargando…

Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome

Cutibacterium acnes, previously known as Proprionobacterium, is a commensal Grampositive bacterium of the skin commonly implicated in prosthetic joint infections. However, it has been documented to play a role in other conditions, including SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis,...

Descripción completa

Detalles Bibliográficos
Autores principales: Corbisiero, Michaele Francesco, Batta, Nisha, Kyllo, Hannah, Smyth, Anthony, Allen, Lorna, Franco-Paredes, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195882/
https://www.ncbi.nlm.nih.gov/pubmed/37214184
http://dx.doi.org/10.1016/j.idcr.2023.e01784
_version_ 1785044226344484864
author Corbisiero, Michaele Francesco
Batta, Nisha
Kyllo, Hannah
Smyth, Anthony
Allen, Lorna
Franco-Paredes, Carlos
author_facet Corbisiero, Michaele Francesco
Batta, Nisha
Kyllo, Hannah
Smyth, Anthony
Allen, Lorna
Franco-Paredes, Carlos
author_sort Corbisiero, Michaele Francesco
collection PubMed
description Cutibacterium acnes, previously known as Proprionobacterium, is a commensal Grampositive bacterium of the skin commonly implicated in prosthetic joint infections. However, it has been documented to play a role in other conditions, including SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare autoinflammatory disorder. Diagnosing SAPHO syndrome is cumbersome, as the clinical manifestations are variable and overlap with many inflammatory joint disorders. Herein, we describe a 56-year-old female patient with a presumed diagnosis of longstanding seronegative rheumatoid arthritis and history of C. acnes prosthetic joint infection following revision arthroplasty of the right shoulder. She presented to our clinic with a rash over the upper extremities and trunk and joint symptoms involving the right shoulder. Treatment was initiated with ceftriaxone followed by doxycycline suppressive therapy, with clinical improvement of joint and skin involvement. Symptoms recurred upon brief cessation of antibiotic therapy due to adverse gastrointestinal effects; however, symptoms abated once again upon re-initiation of treatment. Given the patient’s cutaneous lesions and longstanding history of arthritis that improved with antimicrobial therapy against C. acnes, the diagnosis of SAPHO syndrome was entertained. The present case demonstrates the clinical challenges of diagnosing SAPHO syndrome and the importance of its consideration on the differential for a patient with osteoarticular and cutaneous features. Additional literature is needed to improve diagnostic criteria and treatment guidelines.
format Online
Article
Text
id pubmed-10195882
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-101958822023-05-20 Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome Corbisiero, Michaele Francesco Batta, Nisha Kyllo, Hannah Smyth, Anthony Allen, Lorna Franco-Paredes, Carlos IDCases Case Report Cutibacterium acnes, previously known as Proprionobacterium, is a commensal Grampositive bacterium of the skin commonly implicated in prosthetic joint infections. However, it has been documented to play a role in other conditions, including SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare autoinflammatory disorder. Diagnosing SAPHO syndrome is cumbersome, as the clinical manifestations are variable and overlap with many inflammatory joint disorders. Herein, we describe a 56-year-old female patient with a presumed diagnosis of longstanding seronegative rheumatoid arthritis and history of C. acnes prosthetic joint infection following revision arthroplasty of the right shoulder. She presented to our clinic with a rash over the upper extremities and trunk and joint symptoms involving the right shoulder. Treatment was initiated with ceftriaxone followed by doxycycline suppressive therapy, with clinical improvement of joint and skin involvement. Symptoms recurred upon brief cessation of antibiotic therapy due to adverse gastrointestinal effects; however, symptoms abated once again upon re-initiation of treatment. Given the patient’s cutaneous lesions and longstanding history of arthritis that improved with antimicrobial therapy against C. acnes, the diagnosis of SAPHO syndrome was entertained. The present case demonstrates the clinical challenges of diagnosing SAPHO syndrome and the importance of its consideration on the differential for a patient with osteoarticular and cutaneous features. Additional literature is needed to improve diagnostic criteria and treatment guidelines. Elsevier 2023-05-04 /pmc/articles/PMC10195882/ /pubmed/37214184 http://dx.doi.org/10.1016/j.idcr.2023.e01784 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Corbisiero, Michaele Francesco
Batta, Nisha
Kyllo, Hannah
Smyth, Anthony
Allen, Lorna
Franco-Paredes, Carlos
Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome
title Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome
title_full Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome
title_fullStr Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome
title_full_unstemmed Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome
title_short Clinical spectrum of Cutibacterium acnes infections: The SAPHO syndrome
title_sort clinical spectrum of cutibacterium acnes infections: the sapho syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195882/
https://www.ncbi.nlm.nih.gov/pubmed/37214184
http://dx.doi.org/10.1016/j.idcr.2023.e01784
work_keys_str_mv AT corbisieromichaelefrancesco clinicalspectrumofcutibacteriumacnesinfectionsthesaphosyndrome
AT battanisha clinicalspectrumofcutibacteriumacnesinfectionsthesaphosyndrome
AT kyllohannah clinicalspectrumofcutibacteriumacnesinfectionsthesaphosyndrome
AT smythanthony clinicalspectrumofcutibacteriumacnesinfectionsthesaphosyndrome
AT allenlorna clinicalspectrumofcutibacteriumacnesinfectionsthesaphosyndrome
AT francoparedescarlos clinicalspectrumofcutibacteriumacnesinfectionsthesaphosyndrome