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Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes

Using the Scientific Registry of Transplant Recipients, we examined the association between donor-recipient biologic relationship and long-term recipient and allograft survival among glomerulonephritis (GN) patients. Four GN types were studied: membranous nephropathy, IgA, lupus-associated nephritis...

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Autores principales: El-Rifai, Rasha, Bregman, Adam, Klomjit, Nattawat, Spong, Richard, Jackson, Scott, Nachman, Patrick H., Riad, Samy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195883/
https://www.ncbi.nlm.nih.gov/pubmed/37213488
http://dx.doi.org/10.3389/ti.2023.11068
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author El-Rifai, Rasha
Bregman, Adam
Klomjit, Nattawat
Spong, Richard
Jackson, Scott
Nachman, Patrick H.
Riad, Samy
author_facet El-Rifai, Rasha
Bregman, Adam
Klomjit, Nattawat
Spong, Richard
Jackson, Scott
Nachman, Patrick H.
Riad, Samy
author_sort El-Rifai, Rasha
collection PubMed
description Using the Scientific Registry of Transplant Recipients, we examined the association between donor-recipient biologic relationship and long-term recipient and allograft survival among glomerulonephritis (GN) patients. Four GN types were studied: membranous nephropathy, IgA, lupus-associated nephritis, and focal segmental glomerulosclerosis (FSGS). We identified all adult primary living-donor recipients between 2000 and 2018 (n = 19,668): related (n = 10,437); unrelated (n = 9,231). Kaplan-Meier curves were generated for the recipient, death-censored graft survival and death with functioning graft through ten years post-transplant. Multivariable Cox proportional hazard models were used to examine the association between the donor-recipient relationship and outcomes of interest. There was an increased risk for acute rejection by 12 months post-transplant among the unrelated compared to the related group in IgA (10.1% vs. 6.5%, p<0.001), FSGS (12.1% vs. 10%, p-0.016), and lupus nephritis (11.8% vs. 9.2%; p-0.049). The biological donor-recipient relationship was not associated with a worse recipient or graft survival or death with functioning graft in the multivariable models. These findings are consistent with the known benefits of living-related-donor kidney transplants and counter the reports of the potential adverse impact of the donor-recipient biologic relationship on allograft outcomes.
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spelling pubmed-101958832023-05-20 Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes El-Rifai, Rasha Bregman, Adam Klomjit, Nattawat Spong, Richard Jackson, Scott Nachman, Patrick H. Riad, Samy Transpl Int Health Archive Using the Scientific Registry of Transplant Recipients, we examined the association between donor-recipient biologic relationship and long-term recipient and allograft survival among glomerulonephritis (GN) patients. Four GN types were studied: membranous nephropathy, IgA, lupus-associated nephritis, and focal segmental glomerulosclerosis (FSGS). We identified all adult primary living-donor recipients between 2000 and 2018 (n = 19,668): related (n = 10,437); unrelated (n = 9,231). Kaplan-Meier curves were generated for the recipient, death-censored graft survival and death with functioning graft through ten years post-transplant. Multivariable Cox proportional hazard models were used to examine the association between the donor-recipient relationship and outcomes of interest. There was an increased risk for acute rejection by 12 months post-transplant among the unrelated compared to the related group in IgA (10.1% vs. 6.5%, p<0.001), FSGS (12.1% vs. 10%, p-0.016), and lupus nephritis (11.8% vs. 9.2%; p-0.049). The biological donor-recipient relationship was not associated with a worse recipient or graft survival or death with functioning graft in the multivariable models. These findings are consistent with the known benefits of living-related-donor kidney transplants and counter the reports of the potential adverse impact of the donor-recipient biologic relationship on allograft outcomes. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10195883/ /pubmed/37213488 http://dx.doi.org/10.3389/ti.2023.11068 Text en Copyright © 2023 El-Rifai, Bregman, Klomjit, Spong, Jackson, Nachman and Riad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
El-Rifai, Rasha
Bregman, Adam
Klomjit, Nattawat
Spong, Richard
Jackson, Scott
Nachman, Patrick H.
Riad, Samy
Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
title Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
title_full Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
title_fullStr Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
title_full_unstemmed Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
title_short Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
title_sort living donor kidney transplant in recipients with glomerulonephritis: donor recipient biologic relationship and allograft outcomes
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195883/
https://www.ncbi.nlm.nih.gov/pubmed/37213488
http://dx.doi.org/10.3389/ti.2023.11068
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