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Advances in nanotechnology for the treatment of GBM
Glioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196029/ https://www.ncbi.nlm.nih.gov/pubmed/37214394 http://dx.doi.org/10.3389/fnins.2023.1180943 |
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author | Wei, Dongyan Zhang, Ni Qu, Shuang Wang, Hao Li, Jin |
author_facet | Wei, Dongyan Zhang, Ni Qu, Shuang Wang, Hao Li, Jin |
author_sort | Wei, Dongyan |
collection | PubMed |
description | Glioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasive nature of GBM, it is difficult to completely resect them due to the unclear boundary between the edges of GBM and normal brain tissue. Traditional radiotherapy and the combination of alkylating agents and radiotherapy have significant side effects, therapeutic drugs are difficult to penetrate the blood brain barrier. Patients receiving treatment have a high postoperative recurrence rate and a median survival of less than 2 years, Less than 5% of patients live longer than 5 years. Therefore, it is urgent to achieve precise treatment through the blood brain barrier and reduce toxic and side effects. Nanotechnology exhibit great potential in this area. This article summarizes the current treatment methods and shortcomings of GBM, and summarizes the research progress in the diagnosis and treatment of GBM using nanotechnology. |
format | Online Article Text |
id | pubmed-10196029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101960292023-05-20 Advances in nanotechnology for the treatment of GBM Wei, Dongyan Zhang, Ni Qu, Shuang Wang, Hao Li, Jin Front Neurosci Neuroscience Glioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasive nature of GBM, it is difficult to completely resect them due to the unclear boundary between the edges of GBM and normal brain tissue. Traditional radiotherapy and the combination of alkylating agents and radiotherapy have significant side effects, therapeutic drugs are difficult to penetrate the blood brain barrier. Patients receiving treatment have a high postoperative recurrence rate and a median survival of less than 2 years, Less than 5% of patients live longer than 5 years. Therefore, it is urgent to achieve precise treatment through the blood brain barrier and reduce toxic and side effects. Nanotechnology exhibit great potential in this area. This article summarizes the current treatment methods and shortcomings of GBM, and summarizes the research progress in the diagnosis and treatment of GBM using nanotechnology. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10196029/ /pubmed/37214394 http://dx.doi.org/10.3389/fnins.2023.1180943 Text en Copyright © 2023 Wei, Zhang, Qu, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wei, Dongyan Zhang, Ni Qu, Shuang Wang, Hao Li, Jin Advances in nanotechnology for the treatment of GBM |
title | Advances in nanotechnology for the treatment of GBM |
title_full | Advances in nanotechnology for the treatment of GBM |
title_fullStr | Advances in nanotechnology for the treatment of GBM |
title_full_unstemmed | Advances in nanotechnology for the treatment of GBM |
title_short | Advances in nanotechnology for the treatment of GBM |
title_sort | advances in nanotechnology for the treatment of gbm |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196029/ https://www.ncbi.nlm.nih.gov/pubmed/37214394 http://dx.doi.org/10.3389/fnins.2023.1180943 |
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