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Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis

AIMS: Left ventricular (LV) global longitudinal strain (GLS) (LV-GLS) is a strong and independent predictor of outcomes in patients with immunoglobulin light-chain (AL) cardiac amyloidosis. This study was performed to investigate whether right ventricular (RV) GLS (RV-GLS) provides prognostic inform...

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Autores principales: Usuku, Hiroki, Yamamoto, Eiichiro, Sueta, Daisuke, Noguchi, Momoko, Fujisaki, Tomohiro, Egashira, Koichi, Oike, Fumi, Fujisue, Koichiro, Hanatani, Shinsuke, Arima, Yuichiro, Takashio, Seiji, Kawano, Yawara, Oda, Seitaro, Kawano, Hiroaki, Matsushita, Kenichi, Ueda, Mitsuharu, Matsui, Hirotaka, Matsuoka, Masao, Tsujita, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196102/
https://www.ncbi.nlm.nih.gov/pubmed/37214543
http://dx.doi.org/10.1093/ehjopen/oead048
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author Usuku, Hiroki
Yamamoto, Eiichiro
Sueta, Daisuke
Noguchi, Momoko
Fujisaki, Tomohiro
Egashira, Koichi
Oike, Fumi
Fujisue, Koichiro
Hanatani, Shinsuke
Arima, Yuichiro
Takashio, Seiji
Kawano, Yawara
Oda, Seitaro
Kawano, Hiroaki
Matsushita, Kenichi
Ueda, Mitsuharu
Matsui, Hirotaka
Matsuoka, Masao
Tsujita, Kenichi
author_facet Usuku, Hiroki
Yamamoto, Eiichiro
Sueta, Daisuke
Noguchi, Momoko
Fujisaki, Tomohiro
Egashira, Koichi
Oike, Fumi
Fujisue, Koichiro
Hanatani, Shinsuke
Arima, Yuichiro
Takashio, Seiji
Kawano, Yawara
Oda, Seitaro
Kawano, Hiroaki
Matsushita, Kenichi
Ueda, Mitsuharu
Matsui, Hirotaka
Matsuoka, Masao
Tsujita, Kenichi
author_sort Usuku, Hiroki
collection PubMed
description AIMS: Left ventricular (LV) global longitudinal strain (GLS) (LV-GLS) is a strong and independent predictor of outcomes in patients with immunoglobulin light-chain (AL) cardiac amyloidosis. This study was performed to investigate whether right ventricular (RV) GLS (RV-GLS) provides prognostic information in patients with AL amyloidosis. METHODS AND RESULTS: Among 74 patients who were diagnosed with AL cardiac amyloidosis at Kumamoto University Hospital from December 2005 to December 2022, 65 patients who had enough information for two-dimensional speckle tracking imaging and did not receive chemotherapy before the diagnosis of cardiac amyloidosis were retrospectively analysed. During a median follow-up of 359 days, 29 deaths occurred. In two-dimensional echocardiographic findings, LV-GLS, left atrium reservoir strain (LASr), and RV-GLS were significantly lower in the all-cause death group than in the survival group (LV-GLS: 8.9 ± 4.2 vs. 11.7 ± 3.9, P < 0.01; LASr: 9.06 ± 7.28 vs. 14.09 ± 8.32, P < 0.05; RV-GLS: 12.0 ± 5.1 vs. 16.8 ± 4.0, P < 0.01). Multivariable Cox proportional hazard analysis showed RV-GLS was significantly and independently associated with all-cause death in patients with AL cardiac amyloidosis (hazard ratio 0.85; 95% confidence interval, 0.77–0.94; P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of RV-GLS for all-cause death was 0.774 and that the best cut-off value of RV-GLS was 14.5% (sensitivity, 75%; specificity, 72%). In the Kaplan–Meier analysis, patients with AL cardiac amyloidosis who had low RV-GLS (<14.5%) had a significantly higher probability of all-cause death (P < 0.01). CONCLUSION: RV-GLS has prognostic value in patients with AL cardiac amyloidosis and provides greater prognostic power than LV-GLS and LASr.
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spelling pubmed-101961022023-05-20 Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis Usuku, Hiroki Yamamoto, Eiichiro Sueta, Daisuke Noguchi, Momoko Fujisaki, Tomohiro Egashira, Koichi Oike, Fumi Fujisue, Koichiro Hanatani, Shinsuke Arima, Yuichiro Takashio, Seiji Kawano, Yawara Oda, Seitaro Kawano, Hiroaki Matsushita, Kenichi Ueda, Mitsuharu Matsui, Hirotaka Matsuoka, Masao Tsujita, Kenichi Eur Heart J Open Original Article AIMS: Left ventricular (LV) global longitudinal strain (GLS) (LV-GLS) is a strong and independent predictor of outcomes in patients with immunoglobulin light-chain (AL) cardiac amyloidosis. This study was performed to investigate whether right ventricular (RV) GLS (RV-GLS) provides prognostic information in patients with AL amyloidosis. METHODS AND RESULTS: Among 74 patients who were diagnosed with AL cardiac amyloidosis at Kumamoto University Hospital from December 2005 to December 2022, 65 patients who had enough information for two-dimensional speckle tracking imaging and did not receive chemotherapy before the diagnosis of cardiac amyloidosis were retrospectively analysed. During a median follow-up of 359 days, 29 deaths occurred. In two-dimensional echocardiographic findings, LV-GLS, left atrium reservoir strain (LASr), and RV-GLS were significantly lower in the all-cause death group than in the survival group (LV-GLS: 8.9 ± 4.2 vs. 11.7 ± 3.9, P < 0.01; LASr: 9.06 ± 7.28 vs. 14.09 ± 8.32, P < 0.05; RV-GLS: 12.0 ± 5.1 vs. 16.8 ± 4.0, P < 0.01). Multivariable Cox proportional hazard analysis showed RV-GLS was significantly and independently associated with all-cause death in patients with AL cardiac amyloidosis (hazard ratio 0.85; 95% confidence interval, 0.77–0.94; P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of RV-GLS for all-cause death was 0.774 and that the best cut-off value of RV-GLS was 14.5% (sensitivity, 75%; specificity, 72%). In the Kaplan–Meier analysis, patients with AL cardiac amyloidosis who had low RV-GLS (<14.5%) had a significantly higher probability of all-cause death (P < 0.01). CONCLUSION: RV-GLS has prognostic value in patients with AL cardiac amyloidosis and provides greater prognostic power than LV-GLS and LASr. Oxford University Press 2023-05-09 /pmc/articles/PMC10196102/ /pubmed/37214543 http://dx.doi.org/10.1093/ehjopen/oead048 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Usuku, Hiroki
Yamamoto, Eiichiro
Sueta, Daisuke
Noguchi, Momoko
Fujisaki, Tomohiro
Egashira, Koichi
Oike, Fumi
Fujisue, Koichiro
Hanatani, Shinsuke
Arima, Yuichiro
Takashio, Seiji
Kawano, Yawara
Oda, Seitaro
Kawano, Hiroaki
Matsushita, Kenichi
Ueda, Mitsuharu
Matsui, Hirotaka
Matsuoka, Masao
Tsujita, Kenichi
Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
title Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
title_full Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
title_fullStr Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
title_full_unstemmed Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
title_short Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
title_sort prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196102/
https://www.ncbi.nlm.nih.gov/pubmed/37214543
http://dx.doi.org/10.1093/ehjopen/oead048
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