Targeted CD7 CAR T-cells for treatment of T-Lymphocyte leukemia and lymphoma and acute myeloid leukemia: recent advances

The high expression of CD7 targets in T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoma has attracted considerable attention from researchers. However, because CD7 chimeric antigen receptor (CAR) T-cells undergo fratricide, CD7 CAR T-cells develop an exhaustion phenotype that impairs the ef...

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Detalles Bibliográficos
Autores principales: Liu, Jile, Zhang, Yi, Guo, Ruiting, Zhao, Yifan, Sun, Rui, Guo, Shujing, Lu, Wenyi, Zhao, Mingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196106/
https://www.ncbi.nlm.nih.gov/pubmed/37215124
http://dx.doi.org/10.3389/fimmu.2023.1170968

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