Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4(+) T-cell response with pre-primed responses directed against common cold coronaviruses

INTRODUCTION: The nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC). METHODS: Here, we comprehensively assessed the breadth and specificity of the NSP12-specific T-cell response...

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Detalles Bibliográficos
Autores principales: Westphal, Tim, Mader, Maria, Karsten, Hendrik, Cords, Leon, Knapp, Maximilian, Schulte, Sophia, Hermanussen, Lennart, Peine, Sven, Ditt, Vanessa, Grifoni, Alba, Addo, Marylyn Martina, Huber, Samuel, Sette, Alessandro, Lütgehetmann, Marc, Pischke, Sven, Kwok, William W., Sidney, John, Schulze zur Wiesch, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196118/
https://www.ncbi.nlm.nih.gov/pubmed/37215095
http://dx.doi.org/10.3389/fimmu.2023.1182504

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