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Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides

OBJECTIVES: Serum levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have been used as useful biomarkers for reflecting the activity of large vessel vasculitides (LVV). However, a novel biomarker that could have a complementary role to these markers is still required. In thi...

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Autores principales: Umezawa, Natsuka, Mizoguchi, Fumitaka, Maejima, Yasuhiro, Kimura, Naoki, Hasegawa, Hisanori, Hosoya, Tadashi, Fujimoto, Minoru, Kohsaka, Hitoshi, Naka, Tetsuji, Yasuda, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196172/
https://www.ncbi.nlm.nih.gov/pubmed/37215715
http://dx.doi.org/10.3389/fmed.2023.1153883
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author Umezawa, Natsuka
Mizoguchi, Fumitaka
Maejima, Yasuhiro
Kimura, Naoki
Hasegawa, Hisanori
Hosoya, Tadashi
Fujimoto, Minoru
Kohsaka, Hitoshi
Naka, Tetsuji
Yasuda, Shinsuke
author_facet Umezawa, Natsuka
Mizoguchi, Fumitaka
Maejima, Yasuhiro
Kimura, Naoki
Hasegawa, Hisanori
Hosoya, Tadashi
Fujimoto, Minoru
Kohsaka, Hitoshi
Naka, Tetsuji
Yasuda, Shinsuke
author_sort Umezawa, Natsuka
collection PubMed
description OBJECTIVES: Serum levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have been used as useful biomarkers for reflecting the activity of large vessel vasculitides (LVV). However, a novel biomarker that could have a complementary role to these markers is still required. In this retrospective observational study, we investigated whether leucine-rich α-2 glycoprotein (LRG), a known biomarker in several inflammatory diseases, could be a novel biomarker for LVVs. METHODS: 49 eligible patients with Takayasu arteritis (TAK) or giant cell arteritis (GCA) whose serum was preserved in our laboratory were enrolled. The concentrations of LRG were measured with an enzyme-linked immunosorbent assay. The clinical course was reviewed retrospectively from their medical records. The disease activity was determined according to the current consensus definition. RESULTS: The serum LRG levels were higher in patients with active disease than those in remission, and decreased after the treatments. While LRG levels were positively correlated with both CRP and erythrocyte sedimentation rate, LRG exhibited inferior performance as an indicator of disease activity compared to CRP and ESR. Of 35 CRP-negative patients, 11 had positive LRG. Among the 11 patients, two had active disease. CONCLUSION: This preliminary study indicated that LRG could be a novel biomarker for LVV. Further large studies should be required to promise the significance of LRG in LVV.
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spelling pubmed-101961722023-05-20 Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides Umezawa, Natsuka Mizoguchi, Fumitaka Maejima, Yasuhiro Kimura, Naoki Hasegawa, Hisanori Hosoya, Tadashi Fujimoto, Minoru Kohsaka, Hitoshi Naka, Tetsuji Yasuda, Shinsuke Front Med (Lausanne) Medicine OBJECTIVES: Serum levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have been used as useful biomarkers for reflecting the activity of large vessel vasculitides (LVV). However, a novel biomarker that could have a complementary role to these markers is still required. In this retrospective observational study, we investigated whether leucine-rich α-2 glycoprotein (LRG), a known biomarker in several inflammatory diseases, could be a novel biomarker for LVVs. METHODS: 49 eligible patients with Takayasu arteritis (TAK) or giant cell arteritis (GCA) whose serum was preserved in our laboratory were enrolled. The concentrations of LRG were measured with an enzyme-linked immunosorbent assay. The clinical course was reviewed retrospectively from their medical records. The disease activity was determined according to the current consensus definition. RESULTS: The serum LRG levels were higher in patients with active disease than those in remission, and decreased after the treatments. While LRG levels were positively correlated with both CRP and erythrocyte sedimentation rate, LRG exhibited inferior performance as an indicator of disease activity compared to CRP and ESR. Of 35 CRP-negative patients, 11 had positive LRG. Among the 11 patients, two had active disease. CONCLUSION: This preliminary study indicated that LRG could be a novel biomarker for LVV. Further large studies should be required to promise the significance of LRG in LVV. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10196172/ /pubmed/37215715 http://dx.doi.org/10.3389/fmed.2023.1153883 Text en Copyright © 2023 Umezawa, Mizoguchi, Maejima, Kimura, Hasegawa, Hosoya, Fujimoto, Kohsaka, Naka and Yasuda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Umezawa, Natsuka
Mizoguchi, Fumitaka
Maejima, Yasuhiro
Kimura, Naoki
Hasegawa, Hisanori
Hosoya, Tadashi
Fujimoto, Minoru
Kohsaka, Hitoshi
Naka, Tetsuji
Yasuda, Shinsuke
Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
title Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
title_full Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
title_fullStr Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
title_full_unstemmed Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
title_short Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
title_sort leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196172/
https://www.ncbi.nlm.nih.gov/pubmed/37215715
http://dx.doi.org/10.3389/fmed.2023.1153883
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