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Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies
Background: The effects of conduction system pacing (CSP) compared with conventional biventricular pacing (BVP) on heart function in patients with heart failure remain elusive. Methods: PubMed, Embase, Cochrane’s Library and Web of science databases were searched up to 1 October 2022 for pertinent c...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196184/ https://www.ncbi.nlm.nih.gov/pubmed/37215180 http://dx.doi.org/10.3389/fphys.2023.1125340 |
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author | Zhang, Jie Li, Feng Zhang, Zhi-Yuan Yang, Fan Kong, Qi Chen, Jia-Yi Zhang, Lei Liu, Huan-Huan Chen, Xu-Fei Ye, Yu-Heng Wang, Ru-Xing |
author_facet | Zhang, Jie Li, Feng Zhang, Zhi-Yuan Yang, Fan Kong, Qi Chen, Jia-Yi Zhang, Lei Liu, Huan-Huan Chen, Xu-Fei Ye, Yu-Heng Wang, Ru-Xing |
author_sort | Zhang, Jie |
collection | PubMed |
description | Background: The effects of conduction system pacing (CSP) compared with conventional biventricular pacing (BVP) on heart function in patients with heart failure remain elusive. Methods: PubMed, Embase, Cochrane’s Library and Web of science databases were searched up to 1 October 2022 for pertinent controlled studies. Random or fixed-effect model were used to synthesize the clinical outcomes. Subgroup analysis was performed to screen the potential confounding factors. Results: Fifteen studies including 1,347 patients were enrolled. Compared with BVP, CSP was significantly associated with shortened QRS duration [WMD -22.51 ms; p = 0.000], improved left ventricular ejection fraction [WMD 5.53%; p = 0.000], improved NYHA grade [WMD -0.42; p = 0.000], higher response rate and lower heart failure rehospitalization rate. CSP resulted in better clinical outcomes in higher male proportion group than lower one compared with BVP. No significant differences of clinical outcomes were observed between left bundle branch area pacing (LBBaP) and his bundle pacing (HBP) except the pacing threshold. The pacing threshold of LBBaP was significantly lower than those in BVP and HBP. Conclusion: This study suggests that CSP might be superior to conventional BVP for HF patients. In a higher male proportion group, CSP may be associated with more benefits than BVP. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355991; Identifier: CRD42022355991. |
format | Online Article Text |
id | pubmed-10196184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101961842023-05-20 Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies Zhang, Jie Li, Feng Zhang, Zhi-Yuan Yang, Fan Kong, Qi Chen, Jia-Yi Zhang, Lei Liu, Huan-Huan Chen, Xu-Fei Ye, Yu-Heng Wang, Ru-Xing Front Physiol Physiology Background: The effects of conduction system pacing (CSP) compared with conventional biventricular pacing (BVP) on heart function in patients with heart failure remain elusive. Methods: PubMed, Embase, Cochrane’s Library and Web of science databases were searched up to 1 October 2022 for pertinent controlled studies. Random or fixed-effect model were used to synthesize the clinical outcomes. Subgroup analysis was performed to screen the potential confounding factors. Results: Fifteen studies including 1,347 patients were enrolled. Compared with BVP, CSP was significantly associated with shortened QRS duration [WMD -22.51 ms; p = 0.000], improved left ventricular ejection fraction [WMD 5.53%; p = 0.000], improved NYHA grade [WMD -0.42; p = 0.000], higher response rate and lower heart failure rehospitalization rate. CSP resulted in better clinical outcomes in higher male proportion group than lower one compared with BVP. No significant differences of clinical outcomes were observed between left bundle branch area pacing (LBBaP) and his bundle pacing (HBP) except the pacing threshold. The pacing threshold of LBBaP was significantly lower than those in BVP and HBP. Conclusion: This study suggests that CSP might be superior to conventional BVP for HF patients. In a higher male proportion group, CSP may be associated with more benefits than BVP. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355991; Identifier: CRD42022355991. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10196184/ /pubmed/37215180 http://dx.doi.org/10.3389/fphys.2023.1125340 Text en Copyright © 2023 Zhang, Li, Zhang, Yang, Kong, Chen, Zhang, Liu, Chen, Ye and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Zhang, Jie Li, Feng Zhang, Zhi-Yuan Yang, Fan Kong, Qi Chen, Jia-Yi Zhang, Lei Liu, Huan-Huan Chen, Xu-Fei Ye, Yu-Heng Wang, Ru-Xing Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies |
title | Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies |
title_full | Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies |
title_fullStr | Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies |
title_full_unstemmed | Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies |
title_short | Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies |
title_sort | conduction system pacing is superior to biventricular pacing in patients with heart failure: insights from the pooled clinical studies |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196184/ https://www.ncbi.nlm.nih.gov/pubmed/37215180 http://dx.doi.org/10.3389/fphys.2023.1125340 |
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