Cargando…
Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development
Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease affecting millions worldwide each year. Cholera is a major public health problem, primarily in countries with poor sanitary conditions and regions affected by natural disasters, where access to safe drinking wat...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196187/ https://www.ncbi.nlm.nih.gov/pubmed/37215733 http://dx.doi.org/10.3389/fmed.2023.1155751 |
_version_ | 1785044291492511744 |
---|---|
author | Montero, David A. Vidal, Roberto M. Velasco, Juliana George, Sergio Lucero, Yalda Gómez, Leonardo A. Carreño, Leandro J. García-Betancourt, Richard O’Ryan, Miguel |
author_facet | Montero, David A. Vidal, Roberto M. Velasco, Juliana George, Sergio Lucero, Yalda Gómez, Leonardo A. Carreño, Leandro J. García-Betancourt, Richard O’Ryan, Miguel |
author_sort | Montero, David A. |
collection | PubMed |
description | Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease affecting millions worldwide each year. Cholera is a major public health problem, primarily in countries with poor sanitary conditions and regions affected by natural disasters, where access to safe drinking water is limited. In this narrative review, we aim to summarize the current understanding of the evolution of virulence and pathogenesis of V. cholerae as well as provide an overview of the immune response against this pathogen. We highlight that V. cholerae has a remarkable ability to adapt and evolve, which is a global concern because it increases the risk of cholera outbreaks and the spread of the disease to new regions, making its control even more challenging. Furthermore, we show that this pathogen expresses several virulence factors enabling it to efficiently colonize the human intestine and cause cholera. A cumulative body of work also shows that V. cholerae infection triggers an inflammatory response that influences the development of immune memory against cholera. Lastly, we reviewed the status of licensed cholera vaccines, those undergoing clinical evaluation, and recent progress in developing next-generation vaccines. This review offers a comprehensive view of V. cholerae and identifies knowledge gaps that must be addressed to develop more effective cholera vaccines. |
format | Online Article Text |
id | pubmed-10196187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101961872023-05-20 Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development Montero, David A. Vidal, Roberto M. Velasco, Juliana George, Sergio Lucero, Yalda Gómez, Leonardo A. Carreño, Leandro J. García-Betancourt, Richard O’Ryan, Miguel Front Med (Lausanne) Medicine Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease affecting millions worldwide each year. Cholera is a major public health problem, primarily in countries with poor sanitary conditions and regions affected by natural disasters, where access to safe drinking water is limited. In this narrative review, we aim to summarize the current understanding of the evolution of virulence and pathogenesis of V. cholerae as well as provide an overview of the immune response against this pathogen. We highlight that V. cholerae has a remarkable ability to adapt and evolve, which is a global concern because it increases the risk of cholera outbreaks and the spread of the disease to new regions, making its control even more challenging. Furthermore, we show that this pathogen expresses several virulence factors enabling it to efficiently colonize the human intestine and cause cholera. A cumulative body of work also shows that V. cholerae infection triggers an inflammatory response that influences the development of immune memory against cholera. Lastly, we reviewed the status of licensed cholera vaccines, those undergoing clinical evaluation, and recent progress in developing next-generation vaccines. This review offers a comprehensive view of V. cholerae and identifies knowledge gaps that must be addressed to develop more effective cholera vaccines. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10196187/ /pubmed/37215733 http://dx.doi.org/10.3389/fmed.2023.1155751 Text en Copyright © 2023 Montero, Vidal, Velasco, George, Lucero, Gómez, Carreño, García-Betancourt and O’Ryan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Montero, David A. Vidal, Roberto M. Velasco, Juliana George, Sergio Lucero, Yalda Gómez, Leonardo A. Carreño, Leandro J. García-Betancourt, Richard O’Ryan, Miguel Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
title | Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
title_full | Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
title_fullStr | Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
title_full_unstemmed | Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
title_short | Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
title_sort | vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196187/ https://www.ncbi.nlm.nih.gov/pubmed/37215733 http://dx.doi.org/10.3389/fmed.2023.1155751 |
work_keys_str_mv | AT monterodavida vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT vidalrobertom vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT velascojuliana vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT georgesergio vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT luceroyalda vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT gomezleonardoa vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT carrenoleandroj vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT garciabetancourtrichard vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment AT oryanmiguel vibriocholeraeclassificationpathogenesisimmuneresponseandtrendsinvaccinedevelopment |