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Determinants of tumor immune evasion: the role of T cell exposed motif frequency and mutant amino acid exposure
Few neoepitopes detected in tumor biopsies are immunogenic. Tumor-specific T cell responses require both the presentation of an epitope that differs from wildtype and the presence of T cells with neoepitope-cognate receptors. We show that mutations detected in tumor biopsies result in an increased f...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196236/ https://www.ncbi.nlm.nih.gov/pubmed/37215122 http://dx.doi.org/10.3389/fimmu.2023.1155679 |