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Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene interaction predictions

The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying causes include the effect of food intake on tacrolimus absorption...

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Detalles Bibliográficos
Autores principales:	Loer, Helena Leonie Hanae, Feick, Denise, Rüdesheim, Simeon, Selzer, Dominik, Schwab, Matthias, Teutonico, Donato, Frechen, Sebastian, van der Lee, Maaike, Moes, Dirk Jan A. R., Swen, Jesse J., Lehr, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196430/ https://www.ncbi.nlm.nih.gov/pubmed/36808892 http://dx.doi.org/10.1002/psp4.12946

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