The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies

The main objective of this tutorial is to provide the readers with a roadmap of how to establish increasingly complex target‐mediated drug disposition (TMDD) models for monoclonal antibodies. To this end, we built mathematical models, each with a detailed visualization, starting from the basic TMDD...

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Detalles Bibliográficos
Autores principales: Pressly, Michelle A., Peletier, Lambertus A., Zheng, Songmao, Sharma, Vishnu D., Lien, Yi Ting (Kayla), Wang, Weirong, Zhou, Honghui, Schmidt, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Tutorials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196441/
https://www.ncbi.nlm.nih.gov/pubmed/36752286
http://dx.doi.org/10.1002/psp4.12927

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