Cargando…

Potency testing of cell and gene therapy products

Potency is one of the critical quality attributes of biological medicinal products, defining their biological activity. Potency testing is expected to reflect the Mechanism of Action (MoA) of the medicinal product and ideally the results should correlate with the clinical response. Multiple assay fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salmikangas, Paula, Carlsson, Björn, Klumb, Christophe, Reimer, Tatiana, Thirstrup, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196484/ https://www.ncbi.nlm.nih.gov/pubmed/37215709 http://dx.doi.org/10.3389/fmed.2023.1190016

Ejemplares similares

Chimeric Antigen Receptor T-Cells (CAR T-Cells) for Cancer Immunotherapy – Moving Target for Industry?
por: Salmikangas, Paula, et al.
Publicado: (2018)

Potency assays and biomarkers for cell-based advanced therapy medicinal products
por: Capelli, Chiara, et al.
Publicado: (2023)

Macrophages at the nexus of mesenchymal stromal cell potency: The emerging role of chemokine cooperativity
por: Galipeau, Jacques
Publicado: (2021)

Modeling Bioavailable Concentrations in Zebrafish Cell Lines and Embryos Increases the Correlation of Toxicity Potencies across Test Systems
por: Lungu-Mitea, Sebastian, et al.
Publicado: (2020)

Bovine Mucosal Heparins Are Comparable to Porcine Mucosal Heparin at USP Potency Adjusted Levels
por: Jeske, Walter, et al.
Publicado: (2019)

Gestational Diabetes Mellitus in Pregnancy Increased Erythropoietin Level Affecting Differentiation Potency of Haematopoietic Stem Cell of Umbilical Cord Blood
por: Mohd Idris, Mohd Razif, et al.
Publicado: (2021)

Search, identification, and curation of cell and gene therapy product regulations using augmented intelligent systems
por: Schaut, William, et al.
Publicado: (2023)

Perceptions of Fourth-Year Medical Students on Writing and Presenting Case Reports
por: Jha, Pinky, et al.
Publicado: (2018)

Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency
por: Willis, Gareth R., et al.
Publicado: (2017)

Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action
por: Whitfield, Sarah J. C., et al.
Publicado: (2017)

Chemokine Assay Matrix Defines the Potency of Human Bone Marrow Mesenchymal Stromal Cells
por: Lipat, Ariel Joy, et al.
Publicado: (2022)

Donor‐defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium
por: Bonfield, Tracey L., et al.
Publicado: (2021)

Development of a Robust Consensus Modeling Approach for Identifying Cellular and Media Metabolites Predictive of Mesenchymal Stromal Cell Potency
por: Van Grouw, Alexandria, et al.
Publicado: (2023)

Considering Cell Therapy Product “Good Manufacturing Practice” Status
por: Bedford, Patrick, et al.
Publicado: (2018)

Editorial: Developments in sickle cell disease therapy and potentials for gene therapy
por: Maitta, Robert W., et al.
Publicado: (2023)

Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production
por: Kesewa Layman, Awo Akosua, et al.
Publicado: (2017)

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
por: Singh, Sheo B., et al.
Publicado: (2018)

Potency of botulinum toxin drugs: test systems and labelling
por: Dressler, Dirk, et al.
Publicado: (2022)

Status of Planned and Ongoing Paediatric Trials Investigating COVID-19 Vaccines: A Cross-Sectional Study of Paediatric Clinical Trials Planned in Agreed PIPs and/or Registered in Clinical Trial Databases
por: Christiansen, Helle, et al.
Publicado: (2022)

Editorial: Global excellence in gene and cell therapy: Europe
por: Mendonça, Liliana, et al.
Publicado: (2023)

Heart Rate Variability Analysis in Revascularized Individuals Submitted to an Anaerobic Potency Test
por: Gutian, Geraldo Mendes, et al.
Publicado: (2007)

Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs
por: Postnikova, Elena, et al.
Publicado: (2018)

Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework
por: Carvalho, Marta, et al.
Publicado: (2017)

Potency Testing of Venoms and Antivenoms in Embryonated Eggs: An Ethical Alternative to Animal Testing
por: Verity, Erin E., et al.
Publicado: (2021)

Education for the translation of Advanced Therapy Medicinal Products
por: Adamo, Davide, et al.
Publicado: (2023)

Development of a potency assay for CD34(+) cell-based therapy
por: Aries, Anne, et al.
Publicado: (2023)

Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays
por: Amărandi, Roxana-Maria, et al.
Publicado: (2018)

Stem Cell Therapy Potency in Personalizing Severe COVID-19 Treatment
por: Basiri, Arefeh, et al.
Publicado: (2021)

Potency Assays for Mesenchymal Stromal Cell Secretome-Based Products for Tissue Regeneration
por: Sagaradze, Georgy, et al.
Publicado: (2023)

A DOG TEST FOR MEASURING THE IMMUNIZING POTENCY OF ANTIRABIES VACCINES
por: Webster, Leslie T., et al.
Publicado: (1940)

A MOUSE TEST FOR MEASURING THE IMMUNIZING POTENCY OF ANTIRABIES VACCINES
por: Webster, Leslie T.
Publicado: (1939)

Molecular Testing on Cytology for Gene Fusion Detection
por: Schmitt, Fernando, et al.
Publicado: (2021)

Fluxion Potencies
por: Skinner, Thos.
Publicado: (1882)

For High Potencies
por: Fincke, B.
Publicado: (1897)

The Potency Question
Publicado: (1894)

Barriers to Treg therapy in Europe: From production to regulation
por: Hennessy, Conor, et al.
Publicado: (2023)

Design, production and immunomodulatory potency of a novel allergen bioparticle
por: Gomord, Véronique, et al.
Publicado: (2020)

Experimental study of imiprotrin allergic potency in case of inhalation
por: Hrushka, Oksana, et al.
Publicado: (2019)

Cell and Gene Therapies: European View on Challenges in Translation and How to Address Them
por: Rousseau, Cécile F., et al.
Publicado: (2018)

Bringing function to the forefront of cell therapy: how do we demonstrate potency?
por: Lowdell, Mark W., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t5jlm11q3m7s12fh2nacmatm2f