Cargando…

Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study

Hesperidin (HSP) has multiple beneficial effects in verities of clinical situations including type 2 diabetes mellitus (T2DM). Aim: Determination of curative effects of HSP on the liver in T2DM rats through biochemical and histopathological studies. Methods: Animals. Fifty rats were enrolled. 10 rat...

Descripción completa

Detalles Bibliográficos
Autores principales: Atta, Ihab Shafek, Elnady, Mohamed R., Alghamdi, Ali G., Alghamdi, Ahmed Hassan, Aboulata, Alaa A., Shatla, Ibrahim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196525/
https://www.ncbi.nlm.nih.gov/pubmed/37215885
http://dx.doi.org/10.1016/j.heliyon.2023.e16031
_version_ 1785044374769369088
author Atta, Ihab Shafek
Elnady, Mohamed R.
Alghamdi, Ali G.
Alghamdi, Ahmed Hassan
Aboulata, Alaa A.
Shatla, Ibrahim M.
author_facet Atta, Ihab Shafek
Elnady, Mohamed R.
Alghamdi, Ali G.
Alghamdi, Ahmed Hassan
Aboulata, Alaa A.
Shatla, Ibrahim M.
author_sort Atta, Ihab Shafek
collection PubMed
description Hesperidin (HSP) has multiple beneficial effects in verities of clinical situations including type 2 diabetes mellitus (T2DM). Aim: Determination of curative effects of HSP on the liver in T2DM rats through biochemical and histopathological studies. Methods: Animals. Fifty rats were enrolled. 10 rats were fed a normal diet (control group), and the remaining 40 rats received a high-fat diet (HFD) for 8 weeks. The HFD-fed rats were grouped into Group II: 10 rats, and Group III: 10 rats received HSP 100 mg/kg. Group IV: 10 rats received a single dose of streptozotocin (STZ), 30 mg/kg, and Group V: 10 rats received STZ and HSP. Body weight, Blood glucose, insulin level, liver enzymes, lipid profile, oxidative stress, TNF-α, NF-κB, and liver biopsy were estimated. Results: there is improvement in the histological profile of the steatosis in HFD-fed rats treated with HSP either in group III or in group V (received STZ) along with amelioration in blood glucose, insulin, liver enzymes, lipid profile, oxidative profile, TNF-α, and NF-κB. Conclusion: HSP in this STZ model revealed an improvement in steatosis, biochemical markers, and histologic findings. By studying these factors, we expected to identify the prospective targets for intervention that could help improve outcomes for individuals with obesity and diabetes-related liver diseases.
format Online
Article
Text
id pubmed-10196525
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-101965252023-05-20 Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study Atta, Ihab Shafek Elnady, Mohamed R. Alghamdi, Ali G. Alghamdi, Ahmed Hassan Aboulata, Alaa A. Shatla, Ibrahim M. Heliyon Research Article Hesperidin (HSP) has multiple beneficial effects in verities of clinical situations including type 2 diabetes mellitus (T2DM). Aim: Determination of curative effects of HSP on the liver in T2DM rats through biochemical and histopathological studies. Methods: Animals. Fifty rats were enrolled. 10 rats were fed a normal diet (control group), and the remaining 40 rats received a high-fat diet (HFD) for 8 weeks. The HFD-fed rats were grouped into Group II: 10 rats, and Group III: 10 rats received HSP 100 mg/kg. Group IV: 10 rats received a single dose of streptozotocin (STZ), 30 mg/kg, and Group V: 10 rats received STZ and HSP. Body weight, Blood glucose, insulin level, liver enzymes, lipid profile, oxidative stress, TNF-α, NF-κB, and liver biopsy were estimated. Results: there is improvement in the histological profile of the steatosis in HFD-fed rats treated with HSP either in group III or in group V (received STZ) along with amelioration in blood glucose, insulin, liver enzymes, lipid profile, oxidative profile, TNF-α, and NF-κB. Conclusion: HSP in this STZ model revealed an improvement in steatosis, biochemical markers, and histologic findings. By studying these factors, we expected to identify the prospective targets for intervention that could help improve outcomes for individuals with obesity and diabetes-related liver diseases. Elsevier 2023-05-06 /pmc/articles/PMC10196525/ /pubmed/37215885 http://dx.doi.org/10.1016/j.heliyon.2023.e16031 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Atta, Ihab Shafek
Elnady, Mohamed R.
Alghamdi, Ali G.
Alghamdi, Ahmed Hassan
Aboulata, Alaa A.
Shatla, Ibrahim M.
Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study
title Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study
title_full Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study
title_fullStr Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study
title_full_unstemmed Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study
title_short Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study
title_sort assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type ii diabetes: a histological and biochemical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196525/
https://www.ncbi.nlm.nih.gov/pubmed/37215885
http://dx.doi.org/10.1016/j.heliyon.2023.e16031
work_keys_str_mv AT attaihabshafek assessingthehepatoprotectiveeffectsofhesperidinonliverassociateddisordersinalbinoratswithexperimentallyinducedobesityandtypeiidiabetesahistologicalandbiochemicalstudy
AT elnadymohamedr assessingthehepatoprotectiveeffectsofhesperidinonliverassociateddisordersinalbinoratswithexperimentallyinducedobesityandtypeiidiabetesahistologicalandbiochemicalstudy
AT alghamdialig assessingthehepatoprotectiveeffectsofhesperidinonliverassociateddisordersinalbinoratswithexperimentallyinducedobesityandtypeiidiabetesahistologicalandbiochemicalstudy
AT alghamdiahmedhassan assessingthehepatoprotectiveeffectsofhesperidinonliverassociateddisordersinalbinoratswithexperimentallyinducedobesityandtypeiidiabetesahistologicalandbiochemicalstudy
AT aboulataalaaa assessingthehepatoprotectiveeffectsofhesperidinonliverassociateddisordersinalbinoratswithexperimentallyinducedobesityandtypeiidiabetesahistologicalandbiochemicalstudy
AT shatlaibrahimm assessingthehepatoprotectiveeffectsofhesperidinonliverassociateddisordersinalbinoratswithexperimentallyinducedobesityandtypeiidiabetesahistologicalandbiochemicalstudy