Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease. While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress and is sufficient to drive pathology. Currently, the molecu...

Descripción completa

Detalles Bibliográficos
Autores principales: Cakir, Zeynep, Lord, Samuel J., Zhou, Yuan, Jang, Gwendolyn M., Polacco, Benjamin J., Eckhardt, Manon, Jimenez-Morales, David, Newton, Billy W., Orr, Adam L., Johnson, Jeffrey R., da Cruz, Alexandre, Mullins, R. Dyche, Krogan, Nevan J., Mahley, Robert W., Swaney, Danielle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196575/
https://www.ncbi.nlm.nih.gov/pubmed/37019383
http://dx.doi.org/10.1016/j.mcpro.2023.100541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196575/
https://www.ncbi.nlm.nih.gov/pubmed/37019383
http://dx.doi.org/10.1016/j.mcpro.2023.100541

Ejemplares similares