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Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients
BACKGROUND: The monocyte distribution width (MDW), a novel inflammatory biomarker reflecting morphological changes in response to inflammation, has been shown to be useful in identifying COVID-19 infection or predicting death. However, data on the association with predicting the need for respiratory...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Jaypee Brothers Medical Publishers
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196649/ https://www.ncbi.nlm.nih.gov/pubmed/37214109 http://dx.doi.org/10.5005/jp-journals-10071-24447 |
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author | Daorattanachai, Kiattichai Hirunrut, Chachchom Pirompanich, Pattarin Weschawalit, Sinee Srivilaithon, Winchana |
author_facet | Daorattanachai, Kiattichai Hirunrut, Chachchom Pirompanich, Pattarin Weschawalit, Sinee Srivilaithon, Winchana |
author_sort | Daorattanachai, Kiattichai |
collection | PubMed |
description | BACKGROUND: The monocyte distribution width (MDW), a novel inflammatory biomarker reflecting morphological changes in response to inflammation, has been shown to be useful in identifying COVID-19 infection or predicting death. However, data on the association with predicting the need for respiratory support are still limited. The aim of this study was to determine the association of MDW with the need for respiratory support in patients with SARS-CoV-2 infection. PATIENTS AND METHODS: This is a single-center retrospective cohort study. Consecutive hospitalized COVID-19 adult patients who presented at the outpatient department (OPD) or emergency department (ED) between May and August 2021 were enrolled. Respiratory support was defined as any one of the following: conventional oxygen therapy, high-flow oxygen nasal cannula, noninvasive, or invasive mechanical ventilation. The performance of MDW was measured using the area under the receiver operating characteristic (AuROC) curve. RESULTS: Of the 250 enrolled patients, 122 (48.8%) patients received respiratory support. The mean MDW was significantly higher in the respiratory support group: 27.2 ± 4.6 vs 23.6 ± 4.1 (p < 0.001). The MDW ≥ 25 had the best AuROC characteristics of 0.70 (95% CI: 0.65–0.76). CONCLUSIONS: The MDW is a potential biomarker that may aid in identifying individuals at risk of requiring oxygen support in COVID-19 and can be easily implemented in clinical practice. HOW TO CITE THIS ARTICLE: Daorattanachai K, Hirunrut C, Pirompanich P, Weschawalit S, Srivilaithon W. Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients. Indian J Crit Care Med 2023;27(5):352–357. |
format | Online Article Text |
id | pubmed-10196649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Jaypee Brothers Medical Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-101966492023-05-20 Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients Daorattanachai, Kiattichai Hirunrut, Chachchom Pirompanich, Pattarin Weschawalit, Sinee Srivilaithon, Winchana Indian J Crit Care Med Brief Communication BACKGROUND: The monocyte distribution width (MDW), a novel inflammatory biomarker reflecting morphological changes in response to inflammation, has been shown to be useful in identifying COVID-19 infection or predicting death. However, data on the association with predicting the need for respiratory support are still limited. The aim of this study was to determine the association of MDW with the need for respiratory support in patients with SARS-CoV-2 infection. PATIENTS AND METHODS: This is a single-center retrospective cohort study. Consecutive hospitalized COVID-19 adult patients who presented at the outpatient department (OPD) or emergency department (ED) between May and August 2021 were enrolled. Respiratory support was defined as any one of the following: conventional oxygen therapy, high-flow oxygen nasal cannula, noninvasive, or invasive mechanical ventilation. The performance of MDW was measured using the area under the receiver operating characteristic (AuROC) curve. RESULTS: Of the 250 enrolled patients, 122 (48.8%) patients received respiratory support. The mean MDW was significantly higher in the respiratory support group: 27.2 ± 4.6 vs 23.6 ± 4.1 (p < 0.001). The MDW ≥ 25 had the best AuROC characteristics of 0.70 (95% CI: 0.65–0.76). CONCLUSIONS: The MDW is a potential biomarker that may aid in identifying individuals at risk of requiring oxygen support in COVID-19 and can be easily implemented in clinical practice. HOW TO CITE THIS ARTICLE: Daorattanachai K, Hirunrut C, Pirompanich P, Weschawalit S, Srivilaithon W. Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients. Indian J Crit Care Med 2023;27(5):352–357. Jaypee Brothers Medical Publishers 2023-05 /pmc/articles/PMC10196649/ /pubmed/37214109 http://dx.doi.org/10.5005/jp-journals-10071-24447 Text en Copyright © 2023; The Author(s). https://creativecommons.org/licenses/by-nc/4.0/© The Author(s). 2023 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Brief Communication Daorattanachai, Kiattichai Hirunrut, Chachchom Pirompanich, Pattarin Weschawalit, Sinee Srivilaithon, Winchana Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients |
title | Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients |
title_full | Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients |
title_fullStr | Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients |
title_full_unstemmed | Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients |
title_short | Association of Monocyte Distribution Width with the Need for Respiratory Support in Hospitalized COVID-19 Patients |
title_sort | association of monocyte distribution width with the need for respiratory support in hospitalized covid-19 patients |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196649/ https://www.ncbi.nlm.nih.gov/pubmed/37214109 http://dx.doi.org/10.5005/jp-journals-10071-24447 |
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