A Caenorhabditis elegans model of autosomal dominant adult-onset neuronal ceroid lipofuscinosis identifies ethosuximide as a potential therapeutic

Autosomal dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disorder characterized by progressive dementia and premature death. Four ANCL-causing mutations have been identified, all mapping to the DNAJC5 gene that encodes cysteine string protein α (CSPα). Here, u...

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Detalles Bibliográficos
Autores principales: Barker, Eleanor, Morgan, Alan, Barclay, Jeff W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196665/
https://www.ncbi.nlm.nih.gov/pubmed/36282524
http://dx.doi.org/10.1093/hmg/ddac263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196665/
https://www.ncbi.nlm.nih.gov/pubmed/36282524
http://dx.doi.org/10.1093/hmg/ddac263

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