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Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies
Genomic imprinting can lead to allele-specific expression (ASE), where one allele is preferentially expressed more than the other. Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders, notably autism spectrum disorder (ASD). In this study,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196704/ https://www.ncbi.nlm.nih.gov/pubmed/37215523 http://dx.doi.org/10.1016/j.xinn.2023.100436 |
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author | Lu, Zongyang Li, Jie Lu, Yong Li, Ling Wang, Wei Zhang, Chenchen Xu, Libing Nie, Yanhong Gao, Changshan Bian, Xinyan Liu, Zhen Wang, Guang-Zhong Sun, Qiang |
author_facet | Lu, Zongyang Li, Jie Lu, Yong Li, Ling Wang, Wei Zhang, Chenchen Xu, Libing Nie, Yanhong Gao, Changshan Bian, Xinyan Liu, Zhen Wang, Guang-Zhong Sun, Qiang |
author_sort | Lu, Zongyang |
collection | PubMed |
description | Genomic imprinting can lead to allele-specific expression (ASE), where one allele is preferentially expressed more than the other. Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders, notably autism spectrum disorder (ASD). In this study, we crossed rhesus cynomolgus monkeys to produce hybrid monkeys and established a framework to evaluate their allele-specific gene expression patterns using the parental genomes as a reference. Our proof-of-concept analysis of the hybrid monkeys identified 353 genes with allele-biased expression in the brain, enabling us to determine the chromosomal locations of ASE clusters. Importantly, we confirmed a significant enrichment of ASE genes associated with neuropsychiatric disorders, including ASD, highlighting the potential of hybrid monkey models in advancing our understanding of genomic imprinting. |
format | Online Article Text |
id | pubmed-10196704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101967042023-05-20 Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies Lu, Zongyang Li, Jie Lu, Yong Li, Ling Wang, Wei Zhang, Chenchen Xu, Libing Nie, Yanhong Gao, Changshan Bian, Xinyan Liu, Zhen Wang, Guang-Zhong Sun, Qiang Innovation (Camb) Report Genomic imprinting can lead to allele-specific expression (ASE), where one allele is preferentially expressed more than the other. Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders, notably autism spectrum disorder (ASD). In this study, we crossed rhesus cynomolgus monkeys to produce hybrid monkeys and established a framework to evaluate their allele-specific gene expression patterns using the parental genomes as a reference. Our proof-of-concept analysis of the hybrid monkeys identified 353 genes with allele-biased expression in the brain, enabling us to determine the chromosomal locations of ASE clusters. Importantly, we confirmed a significant enrichment of ASE genes associated with neuropsychiatric disorders, including ASD, highlighting the potential of hybrid monkey models in advancing our understanding of genomic imprinting. Elsevier 2023-05-02 /pmc/articles/PMC10196704/ /pubmed/37215523 http://dx.doi.org/10.1016/j.xinn.2023.100436 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Report Lu, Zongyang Li, Jie Lu, Yong Li, Ling Wang, Wei Zhang, Chenchen Xu, Libing Nie, Yanhong Gao, Changshan Bian, Xinyan Liu, Zhen Wang, Guang-Zhong Sun, Qiang Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
title | Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
title_full | Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
title_fullStr | Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
title_full_unstemmed | Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
title_short | Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
title_sort | cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196704/ https://www.ncbi.nlm.nih.gov/pubmed/37215523 http://dx.doi.org/10.1016/j.xinn.2023.100436 |
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