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Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report
BACKGROUND: Christensenella hongkongensis is an obligately anaerobic, catalase-positive, motile, non-sporulating, gram-positive coccobacillus. Human infections are rare and have not been previously reported in Japan. Herein, we report the first case of perforated peritonitis with C. hongkongensis ba...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196759/ https://www.ncbi.nlm.nih.gov/pubmed/37214185 http://dx.doi.org/10.1016/j.idcr.2023.e01797 |
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author | Itoh, Naoya Akazawa, Nana Ishibana, Yuichi Murakami, Hiromi |
author_facet | Itoh, Naoya Akazawa, Nana Ishibana, Yuichi Murakami, Hiromi |
author_sort | Itoh, Naoya |
collection | PubMed |
description | BACKGROUND: Christensenella hongkongensis is an obligately anaerobic, catalase-positive, motile, non-sporulating, gram-positive coccobacillus. Human infections are rare and have not been previously reported in Japan. Herein, we report the first case of perforated peritonitis with C. hongkongensis bacteremia in Japan. CASE PRESENTATION: A 61-year-old Japanese man with advanced colorectal adenocarcinoma presented with fever and abdominal pain. Abdominal computed tomography revealed a low-density area with thinning of the sigmoid colon wall and air outside the intestinal tract, which was diagnosed as perforated peritonitis. Cultures of the ascitic fluid isolated Bacteroides fragilis, Bacteroides eggerthii, Parabacteroides distasonis, Enterococcus avium, and Candida albicans. Gram-positive rods were detected in the blood culture on admission after 4 days. The isolate was identified as C. hongkongensis via 16S ribosomal RNA (16S rRNA) sequencing. The patient underwent open abdominal washout and drainage via a transverse colon bifurcation colostomy. Intravenous meropenem (3 g/day) was administered for 5 days, followed by intravenous piperacillin-tazobactam (9 g/day) for 6 days, and then levofloxacin (500 mg/day) and metronidazole (1500 mg/day) intravenously for 15 days. Postoperatively, the patient gradually recovered. He was transferred to another palliative care hospital on day 38 after admission for worsening advanced colorectal cancer condition. CONCLUSION: Bacteremia caused by C. hongkongensis is rare. 16S rRNA sequencing should be considered for the identification of gram-positive anaerobic rods that are difficult to diagnose by conventional methods. |
format | Online Article Text |
id | pubmed-10196759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101967592023-05-20 Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report Itoh, Naoya Akazawa, Nana Ishibana, Yuichi Murakami, Hiromi IDCases Case Report BACKGROUND: Christensenella hongkongensis is an obligately anaerobic, catalase-positive, motile, non-sporulating, gram-positive coccobacillus. Human infections are rare and have not been previously reported in Japan. Herein, we report the first case of perforated peritonitis with C. hongkongensis bacteremia in Japan. CASE PRESENTATION: A 61-year-old Japanese man with advanced colorectal adenocarcinoma presented with fever and abdominal pain. Abdominal computed tomography revealed a low-density area with thinning of the sigmoid colon wall and air outside the intestinal tract, which was diagnosed as perforated peritonitis. Cultures of the ascitic fluid isolated Bacteroides fragilis, Bacteroides eggerthii, Parabacteroides distasonis, Enterococcus avium, and Candida albicans. Gram-positive rods were detected in the blood culture on admission after 4 days. The isolate was identified as C. hongkongensis via 16S ribosomal RNA (16S rRNA) sequencing. The patient underwent open abdominal washout and drainage via a transverse colon bifurcation colostomy. Intravenous meropenem (3 g/day) was administered for 5 days, followed by intravenous piperacillin-tazobactam (9 g/day) for 6 days, and then levofloxacin (500 mg/day) and metronidazole (1500 mg/day) intravenously for 15 days. Postoperatively, the patient gradually recovered. He was transferred to another palliative care hospital on day 38 after admission for worsening advanced colorectal cancer condition. CONCLUSION: Bacteremia caused by C. hongkongensis is rare. 16S rRNA sequencing should be considered for the identification of gram-positive anaerobic rods that are difficult to diagnose by conventional methods. Elsevier 2023-05-09 /pmc/articles/PMC10196759/ /pubmed/37214185 http://dx.doi.org/10.1016/j.idcr.2023.e01797 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Itoh, Naoya Akazawa, Nana Ishibana, Yuichi Murakami, Hiromi Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report |
title | Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report |
title_full | Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report |
title_fullStr | Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report |
title_full_unstemmed | Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report |
title_short | Peritonitis with bacteremia due to Christensenella hongkongensis identified via ribosomal RNA sequencing in a Japanese patient with advanced colorectal adenocarcinoma: A case report |
title_sort | peritonitis with bacteremia due to christensenella hongkongensis identified via ribosomal rna sequencing in a japanese patient with advanced colorectal adenocarcinoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196759/ https://www.ncbi.nlm.nih.gov/pubmed/37214185 http://dx.doi.org/10.1016/j.idcr.2023.e01797 |
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