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Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein
Cellular prion protein (PrP(C)) protects neurons against oxidative stress damage. This role is lost upon its misfolding into insoluble prions in prion diseases, and correlated with cytoskeletal breakdown and neurophysiological deficits. Here we used mouse neuronal models to assess how PrP(C) protect...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196843/ https://www.ncbi.nlm.nih.gov/pubmed/37172395 http://dx.doi.org/10.1016/j.redox.2023.102733 |