Structural insights into the substrate recognition of serine palmitoyltransferase from Sphingobacterium multivorum

Serine palmitoyltransferase (SPT) is a key enzyme of sphingolipid biosynthesis, which catalyzes the pyridoxal-5′-phosphate–dependent decarboxylative condensation reaction of l-serine (l-Ser) and palmitoyl-CoA (PalCoA) to form 3-ketodihydrosphingosine called long chain base (LCB). SPT is also able to...

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Detalles Bibliográficos
Autores principales: Ikushiro, Hiroko, Murakami, Taiki, Takahashi, Aya, Katayama, Asuka, Sawai, Taiki, Goto, Haruna, Koolath, Sajeer, Murai, Yuta, Monde, Kenji, Miyahara, Ikuko, Kamiya, Nobuo, Yano, Takato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196870/
https://www.ncbi.nlm.nih.gov/pubmed/37030501
http://dx.doi.org/10.1016/j.jbc.2023.104684

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