Lineage switching of the cellular distribution of BRAF(V600E) in multisystem Langerhans cell histiocytosis

Most children with high-risk Langerhans cell histiocytosis (LCH) have BRAF(V600E) mutation. BRAF(V600E) alleles are detectable in myeloid mononuclear cells at diagnosis but it is not known if the cellular distribution of mutation evolves over time. Here, the profiles of 16 patients with high-risk di...

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Detalles Bibliográficos
Autores principales: Milne, Paul, Bomken, Simon, Slater, Olga, Kumar, Ashish, Nelson, Adam, Roy, Somak, Velazquez, Jessica, Mankad, Kshitij, Nicholson, James, Yeomanson, Dan, Grundy, Richard, Kamal, Ahmed, Penn, Anthony, Pears, Jane, Millen, Gerard, Morland, Bruce, Hayden, James, Lam, Jason, Madkhali, Maymoon, MacDonald, Jamie, Singh, Preeti, Pagan, Sarah, Rodriguez-Galindo, Carlos, Minkov, Milen, Donadieu, Jean, Picarsic, Jennifer, Allen, Carl, Bigley, Venetia, Collin, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196915/
https://www.ncbi.nlm.nih.gov/pubmed/36112425
http://dx.doi.org/10.1182/bloodadvances.2021006732

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