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Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study

BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that has been suggested as a predictor of cardiovascular diseases. High glycated hemoglobin (HbA1c) levels and overweight/obesity are independently associated with elevated hs-CRP; meanwhile, high HbA1c levels are fre...

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Autores principales: Shen, Qianqian, He, Tingchao, Li, Ting, Szeto, Ignatius Man-Yau, Mao, Shuai, Zhong, Wuxian, Li, Pin, Jiang, Hua, Zhang, Yumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196946/
https://www.ncbi.nlm.nih.gov/pubmed/37215204
http://dx.doi.org/10.3389/fnut.2023.1156404
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author Shen, Qianqian
He, Tingchao
Li, Ting
Szeto, Ignatius Man-Yau
Mao, Shuai
Zhong, Wuxian
Li, Pin
Jiang, Hua
Zhang, Yumei
author_facet Shen, Qianqian
He, Tingchao
Li, Ting
Szeto, Ignatius Man-Yau
Mao, Shuai
Zhong, Wuxian
Li, Pin
Jiang, Hua
Zhang, Yumei
author_sort Shen, Qianqian
collection PubMed
description BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that has been suggested as a predictor of cardiovascular diseases. High glycated hemoglobin (HbA1c) levels and overweight/obesity are independently associated with elevated hs-CRP; meanwhile, high HbA1c levels are frequently accompanied by overweight or obesity. However, their joint effect on elevated hs-CRP levels has not been well-established. Therefore, we evaluated whether overweight/obesity modified the association between high HbA1c levels and elevated hs-CRP. METHODS: Based on cross-sectional data from the Chinese Urban Adults Diet and Health Study (CUADHS) in 2016, we included 1,630 adults aged 18–75 years (mean age 50.16 years and 33.6% male). Elevated hs-CRP was defined as serum hs-CRP ≥ 3 and <10 mg/L. The interactive effects of BMI and HbA1c levels on the risk of elevated hs-CRP levels were calculated by using multiple logistic regression models, followed by strata-specific analyses. RESULTS: Individuals with elevated hs-CRP had a higher rate of HbA1c level than those without elevated (25.3 vs. 11.3%, P < 0.001), as well as a higher rate of overweight/obesity (67.1 vs. 43.5%, P < 0.001). Higher HbA1c levels were independently associated with an increased risk of elevated hs-CRP [adjusted odds ratio (aOR) = 2.31, 95% confidence interval (CI): 1.47, 3.65], as well as overweight/obesity with the risk of elevated hs-CRP (aOR = .31, 95% confidenc–3.73). Furthermore, overweight/obesity showed a significant synergistic effect on high HbA1c levels with a higher aOR of 5.25 (2.77, 9.95) (P(interaction) < 0.001). This synergistic effect was more prominent when stratified by age (in 18–44 years old, aOR, 95% CI = 30.90, 4.40–236.47 for interaction vs. 6.46, 1.38–30.23 for high HbA1c only) and gender (in women, aOR, 95% CI = 8.33, 3.80–18.23 for interaction vs. 2.46,1.38–4.40 for high HbA1c only). CONCLUSION: There are synergistic effects of high HbA1c levels and overweight/obesity on the risk of elevated hs-CRP in Chinese adults, with more significant effects in adults aged 18–44 years or females. Intervention strategies for preventing high blood glucose levels and body weight simultaneously may be important for reducing hs-CRP-related diseases. Further studies are needed to confirm this finding in other populations, and its molecular mechanisms need to be elucidated.
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spelling pubmed-101969462023-05-20 Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study Shen, Qianqian He, Tingchao Li, Ting Szeto, Ignatius Man-Yau Mao, Shuai Zhong, Wuxian Li, Pin Jiang, Hua Zhang, Yumei Front Nutr Nutrition BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that has been suggested as a predictor of cardiovascular diseases. High glycated hemoglobin (HbA1c) levels and overweight/obesity are independently associated with elevated hs-CRP; meanwhile, high HbA1c levels are frequently accompanied by overweight or obesity. However, their joint effect on elevated hs-CRP levels has not been well-established. Therefore, we evaluated whether overweight/obesity modified the association between high HbA1c levels and elevated hs-CRP. METHODS: Based on cross-sectional data from the Chinese Urban Adults Diet and Health Study (CUADHS) in 2016, we included 1,630 adults aged 18–75 years (mean age 50.16 years and 33.6% male). Elevated hs-CRP was defined as serum hs-CRP ≥ 3 and <10 mg/L. The interactive effects of BMI and HbA1c levels on the risk of elevated hs-CRP levels were calculated by using multiple logistic regression models, followed by strata-specific analyses. RESULTS: Individuals with elevated hs-CRP had a higher rate of HbA1c level than those without elevated (25.3 vs. 11.3%, P < 0.001), as well as a higher rate of overweight/obesity (67.1 vs. 43.5%, P < 0.001). Higher HbA1c levels were independently associated with an increased risk of elevated hs-CRP [adjusted odds ratio (aOR) = 2.31, 95% confidence interval (CI): 1.47, 3.65], as well as overweight/obesity with the risk of elevated hs-CRP (aOR = .31, 95% confidenc–3.73). Furthermore, overweight/obesity showed a significant synergistic effect on high HbA1c levels with a higher aOR of 5.25 (2.77, 9.95) (P(interaction) < 0.001). This synergistic effect was more prominent when stratified by age (in 18–44 years old, aOR, 95% CI = 30.90, 4.40–236.47 for interaction vs. 6.46, 1.38–30.23 for high HbA1c only) and gender (in women, aOR, 95% CI = 8.33, 3.80–18.23 for interaction vs. 2.46,1.38–4.40 for high HbA1c only). CONCLUSION: There are synergistic effects of high HbA1c levels and overweight/obesity on the risk of elevated hs-CRP in Chinese adults, with more significant effects in adults aged 18–44 years or females. Intervention strategies for preventing high blood glucose levels and body weight simultaneously may be important for reducing hs-CRP-related diseases. Further studies are needed to confirm this finding in other populations, and its molecular mechanisms need to be elucidated. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10196946/ /pubmed/37215204 http://dx.doi.org/10.3389/fnut.2023.1156404 Text en Copyright © 2023 Shen, He, Li, Szeto, Mao, Zhong, Li, Jiang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Shen, Qianqian
He, Tingchao
Li, Ting
Szeto, Ignatius Man-Yau
Mao, Shuai
Zhong, Wuxian
Li, Pin
Jiang, Hua
Zhang, Yumei
Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study
title Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study
title_full Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study
title_fullStr Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study
title_full_unstemmed Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study
title_short Synergistic effects of overweight/obesity and high hemoglobin A1c status on elevated high-sensitivity C-reactive protein in Chinese adults: a cross-sectional study
title_sort synergistic effects of overweight/obesity and high hemoglobin a1c status on elevated high-sensitivity c-reactive protein in chinese adults: a cross-sectional study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196946/
https://www.ncbi.nlm.nih.gov/pubmed/37215204
http://dx.doi.org/10.3389/fnut.2023.1156404
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