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Cellular stress induces non-canonical activation of the receptor tyrosine kinase EphA2 through the p38-MK2-RSK signaling pathway

The receptor tyrosine kinase ephrin type-A receptor 2 (EphA2) is overexpressed in malignant tumors. We previously reported that non-canonical EphA2 phosphorylation at Ser-897 was catalyzed by p90 ribosomal S6 kinase (RSK) via the MEK-ERK pathway in ligand- and tyrosine kinase-independent manners. No...

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Detalles Bibliográficos
Autores principales:	Zhou, Yue, Oki, Ryota, Tanaka, Akihiro, Song, Leixin, Takashima, Atsushi, Hamada, Naru, Yokoyama, Satoru, Yano, Seiji, Sakurai, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196987/ https://www.ncbi.nlm.nih.gov/pubmed/37059179 http://dx.doi.org/10.1016/j.jbc.2023.104699

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