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Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefits. Here, we evaluated deletional hereditary persistence of f...
Autores principales: | Venkatesan, Vigneshwaran, Christopher, Abisha Crystal, Rhiel, Manuel, Azhagiri, Manoj Kumar K., Babu, Prathibha, Walavalkar, Kaivalya, Saravanan, Bharath, Andrieux, Geoffroy, Rangaraj, Sumathi, Srinivasan, Saranya, Karuppusamy, Karthik V., Jacob, Annlin, Bagchi, Abhirup, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Balasubramanian, Poonkuzhali, Pai, Rekha, Marepally, Srujan Kumar, Mohankumar, Kumarasamypet Murugesan, Velayudhan, Shaji R., Boerries, Melanie, Notani, Dimple, Cathomen, Toni, Srivastava, Alok, Thangavel, Saravanabhavan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197010/ https://www.ncbi.nlm.nih.gov/pubmed/37215154 http://dx.doi.org/10.1016/j.omtn.2023.04.024 |
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