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Assessment of drug permeability through an ex vivo porcine round window membrane model

Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear. Invasive surgeries to inject through the round window membrane (RWM) or cochleostomy...

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Detalles Bibliográficos
Autores principales:	Moatti, Adele, Silkstone, Dylan, Martin, Taylor, Abbey, Keith, Hutson, Kendall A, Fitzpatrick, Douglas C, Zdanski, Carlton J, Cheng, Alan G, Ligler, Frances S, Greenbaum, Alon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197016/ https://www.ncbi.nlm.nih.gov/pubmed/37213232 http://dx.doi.org/10.1016/j.isci.2023.106789

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