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Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder with a largely unknown etiology. In this case, we are presenting an 84-year-old male patient who was admitted for acute hypoxemic respiratory failure secondary to coronavirus disease 2019 (COVID-19) infection. He was neu...

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Autores principales: Abu-Abaa, Mohammad, Mousa, Aliaa, Chadalawada, Sindhu, Abdulsahib, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197023/
https://www.ncbi.nlm.nih.gov/pubmed/37214058
http://dx.doi.org/10.7759/cureus.37814
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author Abu-Abaa, Mohammad
Mousa, Aliaa
Chadalawada, Sindhu
Abdulsahib, Ali
author_facet Abu-Abaa, Mohammad
Mousa, Aliaa
Chadalawada, Sindhu
Abdulsahib, Ali
author_sort Abu-Abaa, Mohammad
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder with a largely unknown etiology. In this case, we are presenting an 84-year-old male patient who was admitted for acute hypoxemic respiratory failure secondary to coronavirus disease 2019 (COVID-19) infection. He was neurologically intact. His infection improved and oxygen requirement was gradually weaned off allowing for discharge. However, he was admitted again a month later with progressive dysphagia and aspiration that were confirmed on videofluoroscopic study. He was also found to have mild dysarthria, bulbar muscle weakness, bilateral lower motor neuron facial nerve palsy, diffuse hyporeflexia on four extremities with intact sensory function. Diagnosis of ALS was suspected after extensive workup was pursued and ruled out nutritional, structural, autoimmune, infectious and inflammatory disorders. This case is only the third reported case in medical literature to suggest COVID-19 infection as a triggering/accelerating factor of ALS progression. 
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spelling pubmed-101970232023-05-20 Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report Abu-Abaa, Mohammad Mousa, Aliaa Chadalawada, Sindhu Abdulsahib, Ali Cureus Neurology Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder with a largely unknown etiology. In this case, we are presenting an 84-year-old male patient who was admitted for acute hypoxemic respiratory failure secondary to coronavirus disease 2019 (COVID-19) infection. He was neurologically intact. His infection improved and oxygen requirement was gradually weaned off allowing for discharge. However, he was admitted again a month later with progressive dysphagia and aspiration that were confirmed on videofluoroscopic study. He was also found to have mild dysarthria, bulbar muscle weakness, bilateral lower motor neuron facial nerve palsy, diffuse hyporeflexia on four extremities with intact sensory function. Diagnosis of ALS was suspected after extensive workup was pursued and ruled out nutritional, structural, autoimmune, infectious and inflammatory disorders. This case is only the third reported case in medical literature to suggest COVID-19 infection as a triggering/accelerating factor of ALS progression.  Cureus 2023-04-19 /pmc/articles/PMC10197023/ /pubmed/37214058 http://dx.doi.org/10.7759/cureus.37814 Text en Copyright © 2023, Abu-Abaa et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Abu-Abaa, Mohammad
Mousa, Aliaa
Chadalawada, Sindhu
Abdulsahib, Ali
Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report
title Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report
title_full Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report
title_fullStr Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report
title_full_unstemmed Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report
title_short Bulbar Onset Amyotrophic Lateral Sclerosis in a COVID-19 Patient: A Case Report
title_sort bulbar onset amyotrophic lateral sclerosis in a covid-19 patient: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197023/
https://www.ncbi.nlm.nih.gov/pubmed/37214058
http://dx.doi.org/10.7759/cureus.37814
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