A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix

The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation,...

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Autores principales: Boldyrev, I. A., Shendrikov, V. P., Vostrova, A. G., Vodovozova, E. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2023
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197038/
https://www.ncbi.nlm.nih.gov/pubmed/37252003
http://dx.doi.org/10.1134/S1068162023020061
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author Boldyrev, I. A.
Shendrikov, V. P.
Vostrova, A. G.
Vodovozova, E. L.
author_facet Boldyrev, I. A.
Shendrikov, V. P.
Vostrova, A. G.
Vodovozova, E. L.
author_sort Boldyrev, I. A.
collection PubMed
description The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation, and promotes the release of the nucleic acid into the cytoplasm for its further processing after endocytosis. The present work describes a simple and economical method for the synthesis of the ALC-0315 lipid, which can be taken advantage of in mRNA vaccine production.
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spelling pubmed-101970382023-05-23 A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix Boldyrev, I. A. Shendrikov, V. P. Vostrova, A. G. Vodovozova, E. L. Russ J Bioorg Chem Letter to the Editor The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation, and promotes the release of the nucleic acid into the cytoplasm for its further processing after endocytosis. The present work describes a simple and economical method for the synthesis of the ALC-0315 lipid, which can be taken advantage of in mRNA vaccine production. Pleiades Publishing 2023-05-19 2023 /pmc/articles/PMC10197038/ /pubmed/37252003 http://dx.doi.org/10.1134/S1068162023020061 Text en © The Author(s) 2023, ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2023, Vol. 49, No. 2, pp. 412–415. © The Author(s), 2023. This article is an open access publication.Russian Text © The Author(s), 2023, published in Bioorganicheskaya Khimiya, 2023, Vol. 49, No. 2, pp. 216–220. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Letter to the Editor
Boldyrev, I. A.
Shendrikov, V. P.
Vostrova, A. G.
Vodovozova, E. L.
A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
title A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
title_full A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
title_fullStr A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
title_full_unstemmed A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
title_short A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
title_sort route to synthesize ionizable lipid alc-0315, a key component of the mrna vaccine lipid matrix
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197038/
https://www.ncbi.nlm.nih.gov/pubmed/37252003
http://dx.doi.org/10.1134/S1068162023020061
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