Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

Protein kinase B (AKT) is essential for cell survival, proliferation, and migration and has been associated with several diseases. Here, we demonstrate that inositol polyphosphate multikinase (IPMK’s) lipid kinase property drives AKT activation via increasing membrane localization and activation of...

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Detalles Bibliográficos
Autores principales: Reilly, Luke, Semenza, Evan R., Koshkaryan, George, Mishra, Subrata, Chatterjee, Sujan, Abramson, Efrat, Mishra, Pamela, Sei, Yoshitasu, Wank, Stephen A., Donowitz, Mark, Snyder, Solomon H., Guha, Prasun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197106/
https://www.ncbi.nlm.nih.gov/pubmed/37216099
http://dx.doi.org/10.1016/j.isci.2023.106623

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